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Beta Carotene And Vitamin B6 Intake Make Lupus Less Active

On February, 2016 according to the study, published in the online journal Lupus Science and Medicine, “the association between diet and glucocorticoid (GC) treatment in patients with systemic lupus erythematosus (SLE)”. The researchers found how diet affects the activity of diseases in SLE patients, through the GC treatment. According to researchers, vitamin D does not protect against lupus activity on the other hand beta carotene, vitamin B6 and fatty acid C18:2 do have a protective role. Alcohol was also negatively associated with GC treatment, signifying that intake of alcohol at moderate level can be beneficial for patients. 

Inadequate data is available about the dietary habits of lupus patients, however some studies suggested that people who consume very few vegetables, dietary fiber, calcium, fruits, polyunsaturated fatty acids, vitamin B6 have the poorer nutritional status compared to the other population.

The aim of the study was to discover any relationships occurred among the intake of specific nutrients and disease activity, projected by GC treatment. The researchers examined data from than 100 patients over couple of period. The patients were asked to fill a broad food frequency questionnaire, gathering data on more than 85 food and beverages during the previous year of the study. The data was studied and transcribed to evaluations of more than 40 nutrients.

The research team, characterised GC treatment status into four groups, none, started, discontinued, and continued. Changes of dose over the time characterised into increased, decreased and unchanged. High dose levels and GC treatment were considered to reveal more active SLE and increased and unchanged doses were observed as adverse outcomes.

The results of vitamin D associated with GC was discovered.  Though, once the data was adjusted for consumption of calcium supplements and vitamin D, the association did not hold.

Alcohol was negatively linked with treatment of GC, suggesting a protecting effects.  Vitamin B6, fatty acid C18:2 and beta carotene all were associated well for the protection from unfavourable outcome, however calcium and vitamin B12 increased the probability of unfavourable outcomes. The energy intake was related with higher dose levels of GC, reflecting a well-known observation that GC treatment is associated with increased appetite.

Although the conclusions give some insight into relations among nutrients and lupus activity, the study has limitations.

Analyst View:
Beta carotene is more than just being pretty color and is also used to enhance the human and animal performance. It is an essential nutrients for all animal as well as human. As it is only found in plants and cannot be synthesized by animal or humans requirement of this nutrient is fulfilled by their diets only. The increasing application of beta carotene is in turn driving the growth for beta carotene.  Thus, in future more research and development of new sources and technique will not only increase new market opportunities but also bring in rich gains.

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