Alopecia is a medical condition under which the immune system destroys hair follicles, and after that, severe hair loss is seen in that individual. In such medical conditions, hair can come from any part of the human body and often falls out in circular patches. Alopecia totalis is diagnosed when there is a complete hair loss on the scalp. Such issues can be found in people irrespective of their genders and ages. However, most global cases of Alopecia are found in people under the age of 30.
Specific research studies proved that African American and Hispanic females had a higher lifetime occurrence of the condition. Alopecia’s patterns and determinants have been studied, and pathophysiological variables remain primarily unknown. More study that considers environmental, behavioral, genetic, and socioeconomic factors, as well as healthcare access, is needed.
Report Key Takeaways
Some of the recommended treatments for Alopecia are:
Topically applied 2 percent minoxidil is the currently favored treatment for androgenetic Alopecia. Minoxidil appears to have various effects on the hair follicle. In some cases, it lengthens the period follicles spend in anagen, enlarges the actual follicles, and wakes up catagen follicles. Minoxidil’s method for causing these alterations is unknown. As a result, vellus hairs grow larger and become terminal hairs. Furthermore, shedding is minimized.
In men with Alopecia, this agent has been demonstrated to be effective. However, it is not permissible to use for women who come under the reproductive age. Finasteride has also not been proven effective in postmenopausal women suffering from androgenetic Alopecia.
To treat androgenetic Alopecia, exogenous estrogen was widely used in the past. Nowadays, minoxidil is proved as the most effective solution, more effective, and hence exogenous estrogen is rarely used days. Therefore, it’s highly crucial to select the right oral contraceptive pills. These pills have the least androgenic progestin, which is ideal for the treatment.
Recent Developments Related to Alopecia
- Researchers have recently developed a new advanced medication that could benefit people with Alopecia. Concert Pharmaceuticals is a US pharmaceutical company testing a new twice-daily medication to counteract and reverse rapid hair loss. Four out of ten participants in the study could regenerate 80 percent or more of their hair within a year.
- In March 2022, Kintor Pharmaceutical, a leading biotechnology company, conducted the clinical trial of Phase II for KX-826. The clinical trial attempted to develop a solution for male patients with androgenetic Alopecia. A double-blind, randomized trial for approximately 120 adult males will investigate the efficacy and safety of KX-826 for treating AGA.
- The European Medicines Agency’s (EMA) Committee has recommended Baricitinib, an inhibitor, for approval to treat patients with severe alopecia areata.
Major Players Working on Alopecia
Several leading companies are involved in the research and development of drugs and other solutions related to Alopecia. Arcutis Biotherapeutics, Pfizer, Reistone Biopharma, Bioniz Therapeutics, Concert Pharmaceuticals, and Eli Lilly and Company are among the industry leaders.
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