The recovery period after undergoing CAR-T can vary as per the recovery process of individual’s immune system. The standard recovery period typically spans from 20 to 30 days after the therapy.
CAR (Chimeric antigen receptor, CAR)-T is a technique for modifying immune cells called T cells in the lab such that they can detect and destroy cancer cells. CAR T-cell therapy is sometimes referred to as a sort of cell-based gene therapy as it includes changing the gene inside T cells that empowers them to attack cancer.
CAR-T cell therapy generally entails extracting T cells from the bloodstream and implanting a new gene into those cells that allows them to spot malignancy. T cells are injected back into the bloodstream of patients after the gene is introduced. After the injection they get multiple and then generate a different types of immune responses targeted at destroying cancer cells. There are different types of tumours that found in humans and all these tumours have distinct antigens. As per the antigen of a particular tumour each CAR is specifically tailored.
The healthcare bodies such as The US Food and Drug Administration (FDA) have approved CAR-T cell treatments to treat certain lymphomas and leukaemias, as well as multiple myeloma. CAR-T cell therapy is usually come into practice and implemented in case all other options have been exhausted.
Although CAR-T cell therapy is still in its early stages, the recent studies conducted by various researchers certainly show promising results. For instance, a 2020 trial followed children with acute lymphoblastic leukaemia (ALL). Over 85% of children with ALL went into complete remission immediately after therapy, and among these children 60% remained completely cancer-free 12 months later.
Some of the leading companies that work closely and develop CAR-T cell therapies are Aurora Biopharma, Inc., BioAtla LLC., AbbVie Inc., CARTherics, Amgen, Inc., Carina Biotech, and Atara Biotherapeutics, Inc. A detailed overview of these companies, including their major achievements, product launches, recent studies, and pipeline projects, is thoroughly covered in this pipeline insight.
The recovery period after undergoing CAR-T can vary as per the recovery process of individual’s immune system. The standard recovery period typically spans from 20 to 30 days after the therapy.
Such therapy can have side effects on some patients that might result in headaches, seizures, loss of balance, agitation, twitching, and trouble speaking.
The amount you have to pay for treatment is determined by your unique circumstances, such as the location of the therapy center, the type of insurance coverage you carry, and your eligibility for Medicare.
The evaluation of CAR-T cell treatment is conducted case-by-case basis by the major healthcare providers and leading regulatory organizations across the globe. The US (FDA) generally approves such medications when several clinical trials demonstrate higher rate of success in treatment of specific tumours.
While the medication can help some patients with advanced cancer achieve long-term remissions, it can also bring neurologic adverse effects such tremors, speech issues, seizures, and psychosis.