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Diabetic Macular Edema – Pipeline Insights

Diabetic Macular Edema – Pipeline Insights, Recent Developments, Major Players and Review
Report Book

Published Date: June 2022
Category: Healthcare
Report ID:60555
Report Format: PDF
No of Pages: 85

Rating: Credence Reports

Diabetic macular edema (DME) is a type of eye condition in which the blood vessels in the eye get badly affected. As a result of this medical condition, fluid can leak from the blood vessels, and it flows towards the middle of the retina. The retina is a thin layer of tissue that borders the interior of the eye’s rear wall. As a result, you may lose some or all of your site if it’s not addressed.

The National Eye Institute reports that the DME generally affects around 7.5 lakhs of the US population. According to the research, up to 10% of patients with diabetes may suffer from the problem. In terms of global statistics, the International Diabetes Federation (IDF) estimates that diabetic macular edema affects more than 28 million people globally.

Report Key Takeaways

Some of the recommended treatments for DME:

Focal Laser

Laser light is used in this treatment to destroy the leaking blood vessels in the eyes. This type of laser therapy usually does not cause any discomfort. For such kinds of treatment, it may leave persistent blind patches. However, it also aids in slowing or halting the formation of new blood vessels, which could further impair vision. It helps save the remaining vision, and it may even assist in improving it marginally.


In this treatment, injections of steroids into the eye are used over a certain period to reduce the DME. Steroids may also be used when a person cannot tolerate numerous injections. However, this treatment may increase the risk of cataracts and increased intraocular pressure in the long run.


If the vitreous is dragging on the macula, your doctor is most likely to recommend undergoing surgery. In this example, the macula is restored to its natural form through vitrectomy.

Some of the Drugs recommended for DME:

  • KSI-301: Kodiak Sciences
  • RZ402: Rezolute
  • THR-687: Oxurion
  • UBX 1325: Ascentage Pharma
  • APX3330: Ocuphire Pharma

Recent Developments related to Diabetic Macular Edema

  • Oxurion NV, a leading biopharmaceutical company developing next-generation standard-of-care ophthalmic treatments, announced significant findings from Part A of its Phase 2 study of THR-687, an integrin antagonist, for treating diabetic macular edema.
  • Roche Canada officially announced that they had received approval from Health Canada for VABYSMO®, which will be used to treat diabetic macular edema. The DME has emerged as one of the primary causes of vision loss in the Canadian population.

Major Players Working on Diabetic Macular Edema

Some leading companies dealing with the research and development activities related to the diabetic macular edema industry include Novartis, Momenta Pharmaceuticals, Adverum Biotechnologies, Inc., Roche, and Kodiak Sciences Inc.

These industry-dominant companies are forming strategic alliances to conduct higher R&D activities to identify significant risks and possible solutions that could play a big role in managing DME.

Key Reasons to Purchase This Report

  • The pipeline insights offer a broader outlook of major treatments for DME which covers the entire product development cycle, covering all product types, clinical and non-clinical stages, and product development stages.
  • The pipeline’s assessment part sheds light on the DME commercial assessment as well as a clinical assessment of the pipeline drugs in development.
  • The pipeline insight features detailed information on acquisitions, collaborations, partnerships, and licensing, along with a special emphasis on the evaluation of new DME treatments.

Frequently Asked Questions

What are some commonly observed symptoms of DME?

Diabetic patients are usually at a higher risk that they may get diagnosed with DME certain period of time. A diabetic’s vision should be examined at least once a year, or as prescribed by their eye doctor. Double vision, fuzzy vision, and an increase in eye floaters are all signs of visual alterations.

How do healthcare experts conduct a diagnosis of diabetic macular edema?

In the beginning, your eye doctor will conduct a thorough examination of vision exam before proceeding with the diagnosis part of diabetic macular edema. To conduct a better examination of your retina and find signs of damage, they will also need to widen your pupils

How much time duration it takes to recover from DME?

Some people respond to a single therapy entirely, while others require numerous treatments over a longer period of time.

Which countries are witnessing a higher number of cases of diabetic macular edema?

Asia countries, The U.S., The U.K., and Canada are among the countries that mostly register the cases of diabetic macular edema.

Why does patients having diabetes are more prone to macular edema?

The blood vessels in your eyes become weaker when your blood sugar level rises. In your retina, the light-sensitive area at the back of your eye, this can cause them to leak or grow out of control.

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