Dry Eye Disease- Pipeline Insights, Recent Developments, Major Players and Review

Dry Eye Disease: Overview

Dry eye disease (DED) develops when the eyes produce too few tears or the tears evaporate too quickly. One or both eyes may be affected by the illness. A chronic condition of the corneal surface marked by persistent symptoms of burning or irritation that can further lead to the inflammatory damage to the conjunctiva and cornea if they are not treated in early stage. Some of the common risk factors related to DED include low humidity environments, autoimmune disorders, advancing age, and systemic medications.

The cases of dry eye disease are increasing rapidly with a higher global prevalence that ranges from 20% to 50% in different regions. Women are more prone to get dry eye disease as compared to men, with increased prevalence after menopause. The use of estrogen alone or with progestin can worsen symptoms, and androgen treatment improves dry eye symptoms.

Report Key Takeaways

Recommended Drugs & Treatment for Dry Eye Disease:

Most persons with infrequent or mild dry eye symptoms can get by with using over-the-counter eye drops on a daily basis (artificial tears). You have additional options if your symptoms are persistent and serious. What you do will be determined on the cause of your dry eyes.

  • Drugs

Oil glands can't secrete oil into your tears if they're inflamed around the edge of your eyelids. Antibiotics that are prescribed for eye disease are often taken by mouth, although some are prescribed with ointments or eye drops.

  • Eye Drops

Prescription eye drops containing the immune-suppressing medicine cyclosporine or corticosteroids can help manage inflammation on the surface of your eyes. Because of the potential for negative effects, corticosteroids are not recommended for long-term use.

  • Contact Lenses

Inquire with your doctor about modern contact lenses that are developed to help those who suffer from dry eyes. Contact lenses with special feature that protect the surface of the eyes are also preferred certain patients who are having major issue of dry eyes. Scleral lenses, often known as bandage lenses, are a type of contact lens.

Recent Developments Related to Dry Eye Disease

  • Aerie Pharmaceuticals has recently conducted a Phase III clinical trial that is directed for developing the AR-15512 ophthalmic solution. The solution under development is a target for treating dry eye disease. During this phase III trial, the company has also dosed the first participant. The newly developed solution will be evaluated for the treatment for signs and symptoms in the COMET-2 study.
  • The FDA has given the approval for varenicline nasal spray 0.03 mg. The spray is developed for specifically treating signs of dry eye disease. The FDA approved varenicline nasal spray based on the results of different levels of clinical trials such as MYSTIC, ONSET-1, and ONSET-2. In these trials more than 1000 individuals participated who were having mild to severe DED.

Major Players Working on Dry Eye Disease

Some of the key companies who are involved with the research and development activities related to dry eye disease include Novartis AG. Akorn, Inc., Santen Pharmaceutical Co. Ltd., Johnson & Johnson, Inc., Medicom Healthcare Ltd., Allergan Plc., and Similasan Corporation.

 

Key Reasons to Purchase This Report

  • The pipeline insight encompasses an in-depth assessment of existing drugs available in the industry and carry out the competitive study with the newly developed drugs for the target disease.
  • It is a helpful guide for the stakeholders across the industry, including distributors, product manufacturers, practitioners, patients, and other industry experts.
  • It sheds light on the leading companies operating in this arena, covering their recent activities in terms of product developments, expansions, and strategic collaborations.

Dry eye disease is usually caused by certain medical conditions such as rheumatoid arthritis, blepharitis, lupus, thyroid, and refractive eye surgery.

A full ophthalmologic examination is prescribed for the people who witness symptoms of dry eye disease. A thorough medical and ophthalmological history should be taken, as well as screening for autoimmune illnesses linked to DED.

Eye redness, excessing tearing, itching, light sensitivity, and blurry vision are some of the commonly observed symptoms of dry eye disease.

The symptoms of dry eye disease usually takes three to six months to vanish, but in some cases, the symptoms may last for longer duration.

Dry eye disease is usually persist for a longer time and for many cases cannot be healed completely. It's frequently treatable with medical treatments like prescription eye drops or tears duct plugs, which can also help reduce symptoms.

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Published Date:  Jun 2022
Category:  Pharmaceuticals
Report ID:   60563
Report Format:   PDF
Pages:   90
Rating:    4.8 (56)
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