Follicular Lymphoma - Pipeline Insights, Recent Developments, Major Players and Review

Follicular Lymphoma: Overview

Follicular lymphoma is a type of cancer that starts in your white blood cells and progresses to create new and more serious symptoms, such as cancer spreading to other parts of the body. It is slow-growing cancer and many people with this type of cancer have an excellent quality of life and live for a long period of time. When it's diagnosed, the symptoms are usually moderate or non-existent. Follicular lymphoma starts impacting the mental state of a person before it actually impacts the physical well-being.

Annually, near around 2.7 behind every 100,000 people are found diagnosed with this cancer. It is the most prevalent type of indolent lymphoma, or lymphoma that grows slowly. Follicular lymphoma disease is commonly found in people are 65 and older. The male population is more prone to this disease as compared to females. According to a recent study, people who are having this disease and other slow-growing lymphomas usually also suffers from anxiety.

Report Key Takeaways

Recommended Medications/Treatments for Follicular Lymphoma

  • Radiation therapy

Radiation therapy may be used to treat follicular lymphoma in its early stages. Radiation kills cancer cells by emitting high-energy beams. People who are under the stage 1 or 2 of this disease are frequently given the therapy. In some of the cases, the radiation therapy is enough to cure the cancer.

  • Chemotherapy

Chemotherapy can be used alone or in combination with other therapies by healthcare providers. Chemotherapy is a treatment that uses medications to eliminate cancer cells in the body. It's usually used in proportion of the other treatments such as conjunction with other treatments radiation therapy or monoclonal antibodies.

  • Stem cell transplant

Follicular lymphoma is occasionally treated with a stem cell transplant, especially if the malignancy returns. In these types of surgeries, healthy stem cells are infused into patient’s body for replacing them with damaged bone marrow. It's usually just a possibility for folks who are in generally good health.

  • Monoclonal antibodies

Monoclonal antibodies are commonly used drugs for this cancer that allows immune cells to fight cancer. Rituximab is among one of the widely used monoclonal antibody for treating the follicular lymphoma.

Recent Developments Related to Follicular Lymphoma

Roche has received official grant from the European Commission for Lunsumio with a conditional marketing authorization. The medication is specifically developed for effectively treating the adult patients who have a follicular lymphoma. The antibody is for patients who had undergone at least two systemic treatments previously. According to the company, the antibody is a new immunotherapy type that is a chemotherapy-free and off-the-shelf treatment alternative that improves patient outcomes.

The FDA has approved tisagenlecleucel, also known as Kymriah, to treat adult patients with follicular lymphoma (FL) who have previously failed two or more systemic therapy rounds. Adult patients who are detected with follicular lymphoma cancer can now take the benefit of tisagenlecleucel. It will be the therapy's third indication since it was first approved by the FDA as antigen receptor T-cell therapy.

Major Players Working on Follicular Lymphoma

Leading companies such as ADC Therapeutics, Syndax Pharmaceuticals, Xynomic Pharmaceuticals, Incyte Corporation, Janssen, Merck & Co, Dr Reddy's Laboratories, Shanghai Yingli Pharmaceutical, Genentech, and Novartis are working closely to develop effective solutions for the treatment of follicular lymphoma.

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All of the elements that produce follicular lymphoma are unknown to researchers. They do know that changes in people's chromosomes are primarily responsible for maximum occurrences.

Male population who ages 65 and above are more prone to get the disease.

Swollen lymph nodes, fever, and drenching night sweats are all signs that are related to the follicular lymphoma.

Healthcare experts may use one or multiple test as a part of diagnosis. The tests are positron emission tomography, blood test, biopsy, imaging, and computed tomography scan.

Diffuse large B-cell lymphoma is a type of lymphoma that grows quicker than follicular lymphoma. Transformed lymphoma is frequently more aggressive than non-transformed lymphoma and may necessitate more intensive treatment.

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Published Date:  Jun 2022
Category:  Pharmaceuticals
Report ID:   60567
Report Format:   PDF
Pages:   90
Rating:    4.8 (78)
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