Nitric Oxide Therapy Systems Market

Market Insights

Neonatal pulmonary hypertension develops as a result of abnormalities in the normal circulatory transition that occurs in newborns after birth. It is also considered a syndrome due to the manifestations such as hypoxemia, which is caused by pulmonary hypertension and shunting of the blood at the ductus arteriosus and foramen ovale. Acute respiratory distress syndrome is an acute condition in which the diagnosis is made by measuring the ratio of the partial pressure of oxygen in the arteries to the fraction of oxygen in the inspired air, which is less than 200. Inhaling nitric oxide via the cyclic GMP causes vasodilation and promotes relief in neonatal hypertension and acute respiratory distress syndrome.

The types segment includes portable and fixed nitric oxide therapy systems. The end-user segment comprises hospitals, homecare settings, and clinics. Types and end users are taken into consideration for the market estimation and data forecast for the duration of 2016–2026.

The geography segment is covered in the report’s scope.The market assessment is an effective tool that gives a brief understanding of the existing market trends and competitive landscape and is useful in mapping the current business milieu existing in the nitric oxide therapy systems market. The product range available for the treatment of pulmonary ailments such as neonate pulmonary hypertension and acute respiratory distress syndrome is highlighted in the company profiles section. The market leaders in the global nitric oxide therapy systems market are Bellerophon Therapeutics, BOC Healthcare, Dan Hammer Health Ltd., EKU Elektronik GmbH, GeNO LLC, International Biomedical, SLE, Mallinckrodt Pharmaceuticals, Praxair, Inc., and Vapotherm.

Based on type, the nitric oxide therapy systems market is categorized into:

• Portable Nitric Oxide Therapy Systems
• Fixed Nitric Oxide Therapy Systems

Nitric oxide is generally used in intensive care units of hospitals for the treatment of adult respiratory distress syndrome (ARDS) and neonatal pulmonary hypertension. The therapeutic role of nitric oxide as a relaxing factor of the smooth muscle endothelium leading to the reduction of pulmonary blood pressure and vasodilation of blood vessels was observed decades ago. The mechanism of action of nitric oxide is to relax alveolar smooth muscles by increasing cyclic guanosine monophosphate. Portable nitric oxide therapy systems find tremendous utilization due to their durability and lightweight, which permit their easy installation in intensive care units. They are also available as portable analyzers for the screening of primary ciliary dyskinesias. Fixed nitric oxide therapy systems find application in healthcare institutions such as hospitals and ambulatory care settings due to the ease of fabrication of their auxiliary holding devices with the main gas supply, their low cost, and their versatility in their gas delivery function. The manufacturers spearheading the production of nitric oxide therapy systems are Bellerophon Therapeutics, BOC Healthcare, Dan Hammer Health Ltd., EKU Elektronik GmbH, GeNO LLC, International Biomedical, SLE, Mallinckrodt Pharmaceuticals, Praxair, Inc., and Vapotherm.

Based on end users, the global nitric oxide therapy systems market is categorized into:

• Hospitals
• Homecare Settings
• Clinics

The inhalation of nitric oxide for 8 hours at 25 parts per million (ppm) results in nitric oxide toxicity. Manufacturers are constantly striving to create safety monitoring systems that deliver a consistent flow of nitric oxide in patient-ventilator circuits. Side-stream analysis features are present in the nitric oxide delivery system to constantly monitor the concentrations of nitrogen dioxide, nitric oxide, and oxygen. Recently, NuMed Plus, Inc. filed a patent application for a clinical inhaled nitric oxide delivery system primarily developed for providing high-quality nitric oxide in a medical office environment. Hospitals and clinics currently have a consolidated hold in the nitric oxide therapy systems market on account of the rising prevalence of neonate pulmonary hypertension and the increasing number of pediatric cardiopulmonary bypass surgeries being performed. Homecare settings are rapidly using nitric oxide therapy systems for the treatment of acute respiratory distress syndrome in the geriatric population. It is also used in combination with oxygen for the treatment of chronic obstructive pulmonary disease in adults.

For the purpose of this study, the global nitric oxide therapy systems market is categorized into the following regional and country-specific markets:

• North America

• • U.S.
  • Canada
• Europe
  • U.K.
  • Germany
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • rest of Latin America
• Middle East and Africa
  • GCC
  • Rest of the Middle East and Africa

As per the research findings of the National Center for Health Statistics 2015 report, the age-related mortality rate of acute respiratory distress syndrome is 5.01 per 100,000 persons in the United States. The mortality rate is higher in Caucasian males compared to females. The rising prevalence of acute respiratory distress syndrome and the presence of a well-developed healthcare infrastructure make North America the market leader in nitric oxide therapy systems. The mounting geriatric population seeking treatment for acute respiratory distress syndrome in homecare settings is huge in the Western European region, which influences the market growth of nitric oxide therapy systems in Europe. The rising prevalence of neonatal pulmonary hypertension cases, as well as the competitive market created by the emergence of local players supplying nitric oxide therapy systems, contribute to the Asia-Pacific region’s positive market growth.

Chapter 1. Preface
1.1. Report Scope and Description
1.2. Research Methodology
1.2.1. Phase I-Secondary Research
1.2.2. Phase II-Primary Research
1.2.3. Phase III-Expert Panel Review
1.2.4. Assumptions
1.2.5. Approach Adopted

Chapter 2. Executive Summary
2.1. Global Nitric Oxide Therapy Systems Market Portraiture
2.1.1. Global Nitric Oxide Therapy Systems Market, by Type, 2017
2.1.2. Global Nitric Oxide Therapy Systems Market, by End Users, 2017
2.1.3. Global Nitric Oxide Therapy Systems Market, by Geography, 2017

Chapter 3. Nitric Oxide Therapy Systems Market: Dynamics and Future Outlook
3.1. Market Overview
3.2. Drivers
3.3. Challenges
3.4. Opportunities
3.5. Porter’s Five Forces Analysis
3.6. Attractive Investment Proposition, by Geography
3.7. Top 3 Countries: Global Nitric Oxide Therapy Systems Market, 2016-2026 (US$ Mn)
3.8. Competitive Landscape: Global Nitric Oxide Therapy Systems Market, by Key Players, 2015-2025 (US$ Mn)

Chapter 4. Global Nitric Oxide Therapy Systems Market, by Type, 2016 – 2026 (US$ Mn)
4.1. Overview
4.1.1. Comparative Analysis: Global Nitric Oxide Therapy Systems Market, by Type, 2017 Vs. 2026 (Value %)
4.2. Portable Nitric Oxide Therapy Systems
4.3. Fixed Nitric Oxide Therapy Systems

Chapter 5. Global Nitric Oxide Therapy Systems Market, by End Users, 2016 – 2026 (US$ Mn)
5.1. Overview
5.1.1. Comparative Analysis: Global Nitric Oxide Therapy Systems Market, by End Users, 2017 Vs. 2026 (Value %)
5.2. Hospitals
5.3. Homecare Settings
5.4. Clinics

Chapter 6. Global Nitric Oxide Therapy Systems Market, by Geography, 2016 – 2026 (US$ Mn)
6.1. Overview
6.2. North America Nitric Oxide Therapy Systems Market Analysis, 2016 – 2026
6.2.1. North America Nitric Oxide Therapy Systems Market, by Type, 2016 – 2026 (US$ Mn)
6.2.2. North America Nitric Oxide Therapy Systems Market, by End Users, 2016 – 2026 (US$ Mn)
6.2.3. North America Nitric Oxide Therapy Systems Market, by Country, 2016 – 2026 (US$ Mn)
6.2.3.1. U.S.
6.2.3.2. Canada
6.3. Europe Nitric Oxide Therapy Systems Market Analysis, 2016 – 2026
6.3.1. Europe Nitric Oxide Therapy Systems Market, by Type, 2016 – 2026 (US$ Mn)
6.3.2. Europe Nitric Oxide Therapy Systems Market, by End Users, 2016 – 2026 (US$ Mn)
6.3.3. Europe Nitric Oxide Therapy Systems Market, by Country, 2016 – 2026 (US$ Mn)
6.3.3.1. U.K.
6.3.3.2. Germany
6.3.3.3. Rest of Europe
6.4. Asia Pacific Nitric Oxide Therapy Systems Market Analysis, 2016 – 2026
6.4.1. Asia Pacific Nitric Oxide Therapy Systems Market, by Type, 2016 – 2026 (US$ Mn)
6.4.2. Asia Pacific Nitric Oxide Therapy Systems Market, by End Users, 2016 – 2026 (US$ Mn)
6.4.3. Asia Pacific Nitric Oxide Therapy Systems Market, by Country, 2016 – 2026 (US$ Mn)
6.4.3.1. Japan
6.4.3.2. China
6.4.3.3. India
6.4.3.4. Rest of APAC
6.5. Latin America Nitric Oxide Therapy Systems Market Analysis, 2016 – 2026
6.5.1. Latin America Nitric Oxide Therapy Systems Market, by Type, 2016 – 2026 (US$ Mn)
6.5.2. Latin America Nitric Oxide Therapy Systems Market, by End Users, 2016 – 2026 (US$ Mn)
6.5.3. Latin America Nitric Oxide Therapy Systems Market, by Country, 2016 – 2026 (US$ Mn)
6.5.3.1. Brazil
6.5.3.2. Mexico
6.5.3.3. Rest of Latin America
6.6. Middle East & Africa (MEA) Nitric Oxide Therapy Systems Market Analysis, 2016 – 2026
6.6.1. MEA Nitric Oxide Therapy Systems Market, by Type, 2016 – 2026 (US$ Mn)
6.6.2. MEA Nitric Oxide Therapy Systems Market, by End Users, 2016 – 2026 (US$ Mn)
6.6.3. MEA Nitric Oxide Therapy Systems Market, by Region, 2016 – 2026 (US$ Mn)
6.6.3.1. GCC
6.6.3.2. Rest of MEA

Chapter 7. Company Profiles
7.1. Bellerophon Therapeutics
7.1.1. Business Description
7.1.2. Financial Information (Subject to data availability)
7.1.3. Product Portfolio
7.1.4. Key Developments
7.2. BOC Healthcare
7.3. Dan Hammer Health Ltd.
7.4. EKU Elektronik GmbH
7.5. GeNO, LLC
7.6. International Biomedical
7.7. SLE
7.8. Mallinckrodt Pharmaceuticals
7.9. Praxair, Inc.
7.10. Vapotherm

List of Figures

FIG. 1 Nitric Oxide Therapy Systems: Market Segmentation
FIG. 2 Global Nitric Oxide Therapy Systems Market Share, by Type, 2016 (Value %)
FIG. 3 Global Nitric Oxide Therapy Systems Market, by End Users, 2016 (Value %)
FIG. 4 Global Nitric Oxide Therapy Systems Market Share, by Geography, 2016 (Value %)
FIG. 5 Attractive Investment Proposition, by Geography
FIG. 6 Market Competition Landscape, by Key Players, 2016
FIG. 7 Global Portable Nitric Oxide Therapy Systems Market, 2016 – 2026 (US$ Mn)
FIG. 8 Global Fixed Nitric Oxide Therapy Systems Market, 2016 – 2026 (US$ Mn)
FIG. 9 Global Hospitals Market for Nitric Oxide Therapy Systems, 2016 – 2026 (US$ Mn)
FIG. 10 Global Homecare Settings Market for Nitric Oxide Therapy Systems, 2016 – 2026 (US$ Mn)
FIG. 11 Global Clinics Market for Nitric Oxide Therapy Systems, 2016 – 2026 (US$ Mn)
FIG. 12 U.S. Nitric Oxide Therapy Systems Market, 2016 – 2026 (US$ Mn)
FIG. 13 Canada Nitric Oxide Therapy Systems Market, 2016 – 2026 (US$ Mn)
FIG. 14 U.K. Nitric Oxide Therapy Systems Market, 2016 – 2026 (US$ Mn)
FIG. 15 Germany Nitric Oxide Therapy Systems Market, 2016 – 2026 (US$ Mn)
FIG. 16 Rest of Europe Nitric Oxide Therapy Systems Market, 2016 – 2026 (US$ Mn)
FIG. 17 Japan Nitric Oxide Therapy Systems Market, 2016 – 2026 (US$ Mn)
FIG. 18 China Nitric Oxide Therapy Systems Market, 2016 – 2026 (US$ Mn)
FIG. 19 India Nitric Oxide Therapy Systems Market, 2016 – 2026 (US$ Mn)
FIG. 20 Rest of Asia Pacific Nitric Oxide Therapy Systems Market, 2016 – 2026 (US$ Mn)
FIG. 21 Brazil Nitric Oxide Therapy Systems Market, 2016 – 2026 (US$ Mn)
FIG. 22 Mexico Nitric Oxide Therapy Systems Market, 2016 – 2026 (US$ Mn)
FIG. 23 Rest of Latin America Nitric Oxide Therapy Systems Market, 2016 – 2026 (US$ Mn)
FIG. 24 GCC Nitric Oxide Therapy Systems Market, 2016 – 2026 (US$ Mn)
FIG. 25 Rest of Middle East and Africa Nitric Oxide Therapy Systems Market, 2016 – 2026 (US$ Mn)

List of Tables

TABLE 1 Global Nitric Oxide Therapy Systems Market Portraiture
TABLE 2 Global Nitric Oxide Therapy Systems Market, by Type, 2016 – 2026 (US$ Mn)
TABLE 3 Global Nitric Oxide Therapy Systems Market, by End Users, 2016 – 2026 (US$ Mn)
TABLE 4 Global Nitric Oxide Therapy Systems Market, by Geography, 2016 – 2026 (US$ Mn)
TABLE 5 North America Nitric Oxide Therapy Systems Market, by Type, 2016 – 2026 (US$ Mn)
TABLE 6 North America Nitric Oxide Therapy Systems Market, by End Users, 2016 – 2026 (US$ Mn)
TABLE 7 North America Nitric Oxide Therapy Systems Market, by Country, 2016 – 2026 (US$ Mn)
TABLE 8 Europe Nitric Oxide Therapy Systems Market, by Type, 2016 – 2026 (US$ Mn)
TABLE 9 Europe Nitric Oxide Therapy Systems Market, by End Users, 2016 – 2026 (US$ Mn)
TABLE 10 Europe Nitric Oxide Therapy Systems Market, by Country, 2016 – 2026 (US$ Mn)
TABLE 11 Asia Pacific Nitric Oxide Therapy Systems Market, by Type, 2016 – 2026 (US$ Mn)
TABLE 12 Asia Pacific Nitric Oxide Therapy Systems Market, by End Users, 2016 – 2026 (US$ Mn)
TABLE 13 Asia Pacific Nitric Oxide Therapy Systems Market, by Country, 2016 – 2026 (US$ Mn)
TABLE 14 Latin America Nitric Oxide Therapy Systems Market, by Type, 2016 – 2026 (US$ Mn)
TABLE 15 Latin America Nitric Oxide Therapy Systems Market, by End Users, 2016 – 2026 (US$ Mn)
TABLE 16 Latin America Nitric Oxide Therapy Systems Market, by Country, 2016 – 2026 (US$ Mn)
TABLE 17 Middle East and Africa Nitric Oxide Therapy Systems Market, by Type, 2016 – 2026 (US$ Mn)
TABLE 18 Middle East and Africa Nitric Oxide Therapy Systems Market, by End Users, 2016 – 2026 (US$ Mn)
TABLE 19 Middle East and Africa Nitric Oxide Therapy Systems Market, by Region, 2016 – 2026 (US$ Mn)
TABLE 20 Bellerophon Therapeutics: Company Snapshot (Business Description; Financial Information; Type Portfolio; News Coverage)
TABLE 21 BOC Healthcare: Company Snapshot (Business Description; Financial Information; Type Portfolio; News Coverage)
TABLE 22 Dan Hammer Health Ltd.: Company Snapshot (Business Description; Financial Information; Type Portfolio; News Coverage)
TABLE 23 EKU Elektronik GmbH: Company Snapshot (Business Description; Financial Information; Type Portfolio; News Coverage)
TABLE 24 GeNO LLC: Company Snapshot (Business Description; Financial Information; Type Portfolio; News Coverage)
TABLE 25 International Biomedical: Company Snapshot (Business Description; Financial Information; Type Portfolio; News Coverage)
TABLE 26 SLE: Company Snapshot (Business Description; Financial Information; Type Portfolio; News Coverage)
TABLE 27 Mallinckrodt Pharmaceuticals: Company Snapshot (Business Description; Financial Information; Type Portfolio; News Coverage)
TABLE 28 Praxair, Inc.: Company Snapshot (Business Description; Financial Information; Type Portfolio; News Coverage)
TABLE 29 Vapotherm: Company Snapshot (Business Description; Financial Information; Type Portfolio; News Coverage)