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Aptamers Therapeutics Technologies and Services Market By Application Area (Therapeutics, Research, Diagnostics); By Type of Aptamer (DNA, RNA, Peptide); By Target Indication (Geographic Atrophy, Macular Degeneration, Von Willebrand Diseases, Hemophilia A); By Route of Administration (Intravitreal, Intravenous, Subcutaneous); By Scale of Operation (Small Scale, Medium Scale, Large Scale); By Focus Area (Product Development, Product Commercialization, Technology Integration, Technology Utilization, Others); By Company Size (Very Small, Small, Mid-sized, Large, Very Large) – Growth, Share, Opportunities & Competitive Analysis, 2024 – 2032

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Published: | Report ID: 40945 | Report Format : PDF
Historical Period  2019-2022
Base Year  2023
Forecast Period  2024-2032
Aptamers Therapeutics Technologies and Services Market Size 2024  USD 423.33 Million
Aptamers Therapeutics Technologies and Services Market, CAGR  34%
Aptamers Therapeutics Technologies and Services Market Size 2032  USD 3756.48 Million

Market Overview

The Aptamers Therapeutics Technologies and Services Market is projected to grow from USD 423.33 million in 2024 to USD 3756.48 million by 2032, reflecting a compound annual growth rate (CAGR) of 34%.

The Aptamers Therapeutics Technologies and Services Market is experiencing robust growth driven by the increasing adoption of aptamer-based therapeutics in drug discovery and disease treatment. This surge is fueled by aptamers’ high specificity and affinity for target molecules, making them effective in therapeutic applications such as targeted drug delivery and biomarker discovery. Additionally, advancements in aptamer selection technology and rising investment in biotechnology research are significant trends enhancing market growth. The growing prevalence of chronic diseases and the need for more precise molecular therapies also contribute to the expanding use of aptamers, establishing them as a promising alternative to antibodies in various medical applications.

The Aptamers Therapeutics Technologies and Services Market is globally distributed, featuring key players such as Ajinomoto Bio-Pharma Services, BioSpring, CliniSciences, CMIC Group, Halo-Bio RNAi Therapeutics, LGC Biosearch Technologies, NeoNeuro, New England Biolabs, Nitto Denko Avecia, and NOXXON Pharma. These companies are strategically located across North America, Europe, and Asia, reflecting the market’s international reach. North America dominates the market, driven by advanced biotechnological research facilities and substantial investment in drug development. Europe and Asia-Pacific are also significant, with Europe benefiting from robust research initiatives and Asia-Pacific seeing rapid growth due to expanding pharmaceutical sectors and increasing healthcare expenditure.

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Market Drivers

Advantages of Aptamers Over Traditional Therapeutics

Aptamers present significant advantages over traditional antibody-based therapies, primarily due to their smaller size, higher target affinity and specificity, and engineered low immunogenicity. For instance, they are smaller in size, which allows for better tissue penetration, and they have higher target affinity and specificity, which can be up to 100-fold greater than antibodies. Their engineered low immunogenicity reduces the risk of immune system reactions, making them safer for patients. The unique characteristics of aptamers make them highly attractive for drug development, offering a promising avenue for the advancement of safer and more effective therapeutic options.

Expanding Areas of Application in Therapeutics

Aptamers are gaining traction across a broad spectrum of therapeutic areas, including oncology, autoimmune diseases, infectious diseases, and ophthalmic disorders. In therapeutic applications, aptamers are expanding their reach. For instance, in oncology, aptamers like AS1411 have been used in clinical trials, showing an ability to target nucleolin with high specificity. In the field of ophthalmology, an aptamer known as Pegaptanib has been approved for the treatment of age-related macular degeneration, demonstrating the potential for precise drug delivery.Their adaptability and potential for precise drug delivery are drawing considerable interest from the pharmaceutical sector. Furthermore, engineered aptamers have shown reduced immunogenicity, with reported cases of human anti-mouse antibody (HAMA) responses being less than 0.1%.

Technological Advancements in Aptamer Development

Technological advancements in aptamer development are also noteworthy. For instance, the SELEX process has been refined to reduce the selection time from several weeks to a few days, and the introduction of next-generation sequencing (NGS) has allowed for the analysis of vast aptamer libraries, enhancing the selection of high-affinity candidates. These innovations contribute to the generation of aptamers that are not only potent but also highly specific to their target molecules, with some showing over 1000-fold selectivity for their intended targets.

Growing Investment and Regulatory Milestones

Increased funding from pharmaceutical companies, biotech firms, and governmental bodies is catalyzing extensive research and development in aptamer technologies. This financial backing is crucial in advancing the clinical trial pipeline for aptamer-based drugs. The historical approval of Pegaptanib (Macugen) by the FDA in 2004 marked a significant regulatory milestone, enhancing market acceptance and setting a precedent for future approvals. Additionally, the rising demand for personalized medicine underscores the need for targeted therapies, where aptamers’ customizable properties align perfectly with individualized treatment strategies, thereby amplifying their market potential.

Market Trends

Enhancing Aptamer Efficacy through Technological Innovations

The pursuit of high-affinity aptamers is at the forefront of current market trends, driven by advancements in selection techniques and aptamer engineering. Researchers are developing methods to create aptamers with heightened affinity and specificity for their intended targets, which not only enhances their therapeutic efficacy but also minimizes off-target effects. The pursuit of high-affinity aptamers is a key trend in the market, with researchers focusing on creating aptamers that exhibit 10 to 100-fold greater affinity and specificity for their targets. For instance, some engineered aptamers have demonstrated dissociation constants (K_d) in the sub-nanomolar range, significantly enhancing their therapeutic efficacy and reducing off-target effects. This focus ensures aptamers are more effective in clinical settings, providing a strong foundation for their use in precision medicine. Concurrently, the field is witnessing a surge in novel applications for aptamers, moving beyond traditional injectable forms. There is significant exploration into aptamer-drug conjugates, which promise targeted drug delivery, and the potential use of aptamers in gene therapy and topical treatments. These developments are expanding the utility of aptamers across various medical domains, showcasing their versatility and adaptability in addressing complex therapeutic challenges.

Streamlining Aptamer Development with Strategic Collaborations and AI Integration

Efficient delivery systems are critical to the success of aptamer therapeutics. Innovations in nanoparticle technology, liposomes, and bioconjugation are enhancing the stability, bioavailability, and targeted delivery of aptamers within the body. For instance, aptamer-functionalized nanoparticles have shown increased circulation times and targeted delivery, with some studies reporting tumor accumulation rates 10 times higher than non-targeted nanoparticles. These advancements are crucial for the practical application of aptamers in a clinical context. Alongside these technological strides, the rise of Contract Research Organizations (CROs) specializing in aptamer technologies is reshaping the industry landscape. Pharmaceutical companies are increasingly partnering with CROs to accelerate the development process while focusing on their core competencies, a move that leverages specialized expertise without diluting organizational focus. Additionally, the integration of Artificial Intelligence (AI) in the aptamer development process is revolutionizing discovery and optimization. AI algorithms are used to sift through extensive datasets to identify and optimize potential aptamer candidates, significantly speeding up the development pipeline and enhancing the precision of aptamer selection. This integration of AI is setting a new benchmark in the rapid, cost-effective development of next-generation aptamers, fortifying their role in future therapeutic solutions.

Market Challenges Analysis

Navigating High Costs and Regulatory Challenges in Aptamer Development

Developing aptamer-based therapeutics presents a significant financial challenge, as these processes are typically more costly compared to traditional small molecule drugs. The intricate selection processes, coupled with rigorous in vitro and in vivo testing required to prove efficacy and safety, demand substantial investment. Additionally, scaling up production to meet commercial demands while maintaining quality can be resource-intensive. Furthermore, regulatory uncertainties compound these challenges as the approval pathways for aptamers are still under development. Companies face ambiguous requirements regarding the comprehensive data needed for regulatory approvals, which can delay or obstruct the market entry of new aptamer-based drugs.

Overcoming Manufacturing Complexities and Establishing Market Competitiveness

Manufacturing aptamers on a large scale involves complex processes that must ensure high consistency and quality. Developing efficient, cost-effective manufacturing techniques is essential for the commercial viability of aptamers. This necessity is underscored by the limited clinical data available for aptamers, which can hinder their acceptance compared to more extensively studied traditional therapies. Rigorous and expansive clinical trials are required to establish the long-term safety and efficacy of aptamers across diverse patient populations. The intellectual property landscape also presents hurdles, with complexities in patenting aptamers and their targets potentially impeding innovation and commercial strategies. Moreover, aptamers must demonstrate clear clinical advantages over established therapies to gain a foothold in the competitive pharmaceutical market. Addressing these issues is crucial for advancing aptamers as a viable therapeutic option. Additionally, the emerging field of aptamer technology faces a shortage of skilled professionals with specialized expertise in aptamer discovery and engineering, highlighting the need for focused educational and training programs to cultivate a new generation of researchers in this promising area.

Market Segmentation Analysis:

By Application Area:

The Aptamers Therapeutics Technologies and Services Market is distinctly segmented into therapeutics, research, and diagnostics, each serving crucial roles. In therapeutics, aptamers are utilized to develop innovative drugs that offer targeted treatment options for a range of diseases, enhancing efficacy and minimizing side effects compared to traditional therapies. The research segment leverages aptamers for their high specificity and binding capabilities to study cellular interactions and disease mechanisms, facilitating significant advancements in biomedical research. In diagnostics, aptamers are employed as bio-recognition elements in biosensors and diagnostic kits, providing rapid and accurate detection of biomarkers for various diseases, thus improving the speed and accuracy of diagnostic processes.

By Type of Aptamer:

Within the Aptamers Therapeutics Technologies and Services Market, the segmentation by type of aptamer—DNA, RNA, and Peptide—highlights their diverse applications and functionalities. DNA aptamers are popular due to their stability and ease of synthesis, making them suitable for therapeutic and diagnostic applications. RNA aptamers are valued for their flexibility and high specificity, which are advantageous in dynamic therapeutic environments. Peptide aptamers, though less common, offer unique binding capabilities that can interrupt protein-protein interactions, which are crucial in targeted therapies. Each type of aptamer brings distinct properties to the table, catering to specific needs across various medical and research applications, driving innovation within the field.


Based on Application Area:

  • Therapeutics
  • Research
  • Diagnostics

Based on Type of Aptamer:

  • DNA
  • RNA
  • Peptide

Based on Target Indication:

  • Geographic Atrophy
  • Macular Degeneration
  • Von Willebrand Diseases
  • Hemophilia A

Based on Route of Administration:

  • Intravitreal
  • Intravenous
  • Subcutaneous

Based on Scale of Operation:

  • Small Scale
  • Medium Scale
  • Large Scale

Based on Focus Area:

  • Product Development
  • Product Commercialization
  • Technology Integration
  • Technology Utilization
  • Others

Based on Company Size:

  • Very Small
  • Small
  • Mid-sized
  • Large
  • Very Large

Based on the Geography:

  • North America
    • The U.S.
    • Canada
    • Mexico
  • Europe
    • Germany
    • France
    • The U.K.
    • Italy
    • Spain
    • Rest of Europe
  • Asia Pacific
    • China
    • Japan
    • India
    • South Korea
    • South-east Asia
    • Rest of Asia Pacific
  • Latin America
    • Brazil
    • Argentina
    • Rest of Latin America
  • Middle East & Africa
    • GCC Countries
    • South Africa
    • Rest of Middle East and Africa

Regional Analysis

North America:

North America holds a dominant position in the global aptamers therapeutics technologies and services market, capturing a significant market share of approximately 38%. The region’s well-established biotechnology and pharmaceutical industries, along with robust research and development activities, drive the demand for aptamer-based therapeutics. The United States, being a major contributor, boasts a strong presence of leading companies and research institutions actively involved in the development of aptamer-based therapies. Key players operating in the North American market include SomaLogic, Base Pair Biotechnologies, and NeoVentures Biotechnology.


Europe accounts for a substantial market share of around 28% in the aptamers therapeutics technologies and services market. The region’s focus on innovative drug development and the presence of renowned research institutions have contributed to the growth of the aptamer therapeutics market. Countries like Germany, the United Kingdom, and France are major contributors, with well-established biotechnology sectors and a strong emphasis on research and development. Notable players operating in the European market include Aptamera, Inc., Aptamers Consultancy, and APTSCI Biotech.

Key Player Analysis

  • Ajinomoto Bio-Pharma Services
  • BioSpring
  • CliniSciences
  • CMIC Group
  • Halo-Bio RNAi Therapeutics
  • LGC Biosearch Technologies
  • NeoNeuro
  • New England Biolabs
  • Nitto Denko Avecia
  • NOXXON Pharma

Competitive Analysis

In the competitive landscape of the Aptamers Therapeutics Technologies and Services Market, leading players like Ajinomoto Bio-Pharma Services, New England Biolabs, and Nitto Denko Avecia distinguish themselves through innovative aptamer synthesis and comprehensive service offerings. Ajinomoto Bio-Pharma Services excels in providing custom aptamer services tailored for therapeutic applications, leveraging their expertise in molecular biology to enhance drug delivery mechanisms. New England Biolabs focuses on high-quality reagents for aptamer selection, supporting researchers and developers with robust tools for innovative therapeutic solutions. Nitto Denko Avecia leads with significant investments in scaling up aptamer manufacturing, ensuring high-quality production for clinical applications. These companies drive the market by pushing the boundaries of aptamer technology, focusing on reliability, scalability, and customization to meet the diverse needs of their global client base, thus maintaining their competitive edge in a rapidly evolving industry.

Recent Developments

  • In September 2023, Somalogic extended it 2021 partnership with Novo Nordisk till 2025. Using Somalogic’s platform (which includes modified aptamers), Novo Nordisk will continue the drug development efforts in the field of NASH, diabetes and cardiovascular disorders.
  • In July 2023, Zentek and McMaster University announced the development of a novel aptamer technology platform with an increased aptamer binding affinity. The platform enhances the sensitivity of aptamer-based diagnostics for identifying different biomarkers.
  • In April 2023, researchers from the University of Toronto, Canada and Northwestern University, IL, USA developed a novel biosensor, utilizing DNA aptamers for the detection of disease biomarker in complex blood samples.

Market Concentration & Characteristics

The Aptamers Therapeutics Technologies and Services Market exhibits a moderate level of market concentration, with several key players such as Ajinomoto Bio-Pharma Services, New England Biolabs, and Nitto Denko Avecia leading the field. These companies hold significant market shares due to their advanced technological capabilities, extensive experience, and broad service offerings that span from aptamer development to large-scale manufacturing. The market is characterized by intense research and development activities, as companies strive to innovate and refine aptamer technologies to overcome the limitations of traditional therapeutics. Furthermore, the industry sees strategic collaborations and partnerships as essential for advancing aptamer applications in clinical settings. These dynamics reflect a competitive yet collaborative market environment, where innovation and strategic alliances drive growth and expansion. The presence of a diverse range of players, from specialized biotech firms to major pharmaceutical companies, contributes to the dynamic nature of the market, fostering continuous technological advancements and expanding the scope of aptamer applications.

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Report Coverage

The research report offers an in-depth analysis based on Application Area, Type of Aptamer, Target Indication, Route of Administration, Scale of Operation, Focus Area, Company Size and Geography. It details leading market players, providing an overview of their business, product offerings, investments, revenue streams, and key applications. Additionally, the report includes insights into the competitive environment, SWOT analysis, current market trends, as well as the primary drivers and constraints. Furthermore, it discusses various factors that have driven market expansion in recent years. The report also explores market dynamics, regulatory scenarios, and technological advancements that are shaping the industry. It assesses the impact of external factors and global economic changes on market growth. Lastly, it provides strategic recommendations for new entrants and established companies to navigate the complexities of the market.

Future Outlook

  1. Continued expansion driven by the rising demand for targeted and personalized therapeutics.
  2. Increased investment in R&D activities to explore new applications of aptamers in therapeutics and diagnostics.
  3. Growth in partnerships between biotech firms and pharmaceutical giants to accelerate product development.
  4. Advancements in aptamer selection technologies, enhancing specificity and binding capabilities.
  5. Expansion of clinical trials to validate the efficacy and safety of aptamer-based treatments.
  6. Broader adoption of aptamers in diagnostic applications due to their high sensitivity and specificity.
  7. Development of novel manufacturing techniques to enable large-scale production of aptamers.
  8. Strengthening of intellectual property portfolios to secure competitive advantages in the market.
  9. Rise in regulatory approvals for aptamer-based products, increasing their commercial viability.
  10. Growing application of aptamers in emerging fields such as environmental monitoring and food safety.

1. Introduction
1.1. Report Description
1.2. Purpose of the Report
1.3. USP & Key Offerings
1.4. Key Benefits for Stakeholders
1.5. Target Audience
1.6. Report Scope
1.7. Regional Scope
2. Scope and Methodology
2.1. Objectives of the Study
2.2. Stakeholders
2.3. Data Sources
2.3.1. Primary Sources
2.3.2. Secondary Sources
2.4. Market Estimation
2.4.1. Bottom-Up Approach
2.4.2. Top-Down Approach
2.5. Forecasting Methodology
3. Executive Summary
4. Introduction
4.1. Overview
4.2. Key Industry Trends
5. Global Aptamers Therapeutics Technologies and Services Market
5.1. Market Overview
5.2. Market Performance
5.3. Impact of COVID-19
5.4. Market Forecast
6. Market Breakup by Application Area
6.1. Therapeutics
6.1.1. Market Trends
6.1.2. Market Forecast
6.1.3. Revenue Share
6.1.4. Revenue Growth Opportunity
6.2. Research
6.2.1. Market Trends
6.2.2. Market Forecast
6.2.3. Revenue Share
6.2.4. Revenue Growth Opportunity
6.3. Diagnostics
6.3.1. Market Trends
6.3.2. Market Forecast
6.3.3. Revenue Share
6.3.4. Revenue Growth Opportunity
7. Market Breakup by Type of Aptamer
7.1. DNA
7.1.1. Market Trends
7.1.2. Market Forecast
7.1.3. Revenue Share
7.1.4. Revenue Growth Opportunity
7.2. RNA
7.2.1. Market Trends
7.2.2. Market Forecast
7.2.3. Revenue Share
7.2.4. Revenue Growth Opportunity
7.3. Peptide
7.3.1. Market Trends
7.3.2. Market Forecast
7.3.3. Revenue Share
7.3.4. Revenue Growth Opportunity
8. Market Breakup by Target Indication
8.1. Geographic Atrophy
8.1.1. Market Trends
8.1.2. Market Forecast
8.1.3. Revenue Share
8.1.4. Revenue Growth Opportunity
8.2. Macular Degeneration
8.2.1. Market Trends
8.2.2. Market Forecast
8.2.3. Revenue Share
8.2.4. Revenue Growth Opportunity
8.3. Von Willebrand Diseases
8.3.1. Market Trends
8.3.2. Market Forecast
8.3.3. Revenue Share
8.3.4. Revenue Growth Opportunity
8.4. Hemophilia A
8.4.1. Market Trends
8.4.2. Market Forecast
8.4.3. Revenue Share
8.4.4. Revenue Growth Opportunity
9. Market Breakup by Route of Administration
9.1. Intravitreal
9.1.1. Market Trends
9.1.2. Market Forecast
9.1.3. Revenue Share
9.1.4. Revenue Growth Opportunity
9.2. Intravenous
9.2.1. Market Trends
9.2.2. Market Forecast
9.2.3. Revenue Share
9.2.4. Revenue Growth Opportunity
9.3. Subcutaneous
9.3.1. Market Trends
9.3.2. Market Forecast
9.3.3. Revenue Share
9.3.4. Revenue Growth Opportunity
10. Market Breakup by Scale of Operation
10.1. Small Scale
10.1.1. Market Trends
10.1.2. Market Forecast
10.1.3. Revenue Share
10.1.4. Revenue Growth Opportunity
10.2. Medium Scale
10.2.1. Market Trends
10.2.2. Market Forecast
10.2.3. Revenue Share
10.2.4. Revenue Growth Opportunity
10.3. Large Scale
10.3.1. Market Trends
10.3.2. Market Forecast
10.3.3. Revenue Share
10.3.4. Revenue Growth Opportunity
11. Market Breakup by Focus Area
11.1. Product Development
11.1.1. Market Trends
11.1.2. Market Forecast
11.1.3. Revenue Share
11.1.4. Revenue Growth Opportunity
11.2. Product Commercialization
11.2.1. Market Trends
11.2.2. Market Forecast
11.2.3. Revenue Share
11.2.4. Revenue Growth Opportunity
11.3. Technology Integration
11.3.1. Market Trends
11.3.2. Market Forecast
11.3.3. Revenue Share
11.3.4. Revenue Growth Opportunity
11.4. Technology Utilization
11.4.1. Market Trends
11.4.2. Market Forecast
11.4.3. Revenue Share
11.4.4. Revenue Growth Opportunity
11.5. Others
11.5.1. Market Trends
11.5.2. Market Forecast
11.5.3. Revenue Share
11.5.4. Revenue Growth Opportunity
12. Market Breakup by Company Size
12.1. Very Small
12.1.1. Market Trends
12.1.2. Market Forecast
12.1.3. Revenue Share
12.1.4. Revenue Growth Opportunity
12.2. Small
12.2.1. Market Trends
12.2.2. Market Forecast
12.2.3. Revenue Share
12.2.4. Revenue Growth Opportunity
12.3. Mid-sized
12.3.1. Market Trends
12.3.2. Market Forecast
12.3.3. Revenue Share
12.3.4. Revenue Growth Opportunity
12.4. Large
12.4.1. Market Trends
12.4.2. Market Forecast
12.4.3. Revenue Share
12.4.4. Revenue Growth Opportunity
12.5. Very Large
12.5.1. Market Trends
12.5.2. Market Forecast
12.5.3. Revenue Share
12.5.4. Revenue Growth Opportunity
13. Market Breakup by Region
13.1. North America
13.1.1. United States Market Trends Market Forecast
13.1.2. Canada Market Trends Market Forecast
13.2. Asia-Pacific
13.2.1. China
13.2.2. Japan
13.2.3. India
13.2.4. South Korea
13.2.5. Australia
13.2.6. Indonesia
13.2.7. Others
13.3. Europe
13.3.1. Germany
13.3.2. France
13.3.3. United Kingdom
13.3.4. Italy
13.3.5. Spain
13.3.6. Russia
13.3.7. Others
13.4. Latin America
13.4.1. Brazil
13.4.2. Mexico
13.4.3. Others
13.5. Middle East and Africa
13.5.1. Market Trends
13.5.2. Market Breakup by Country
13.5.3. Market Forecast
14. SWOT Analysis
14.1. Overview
14.2. Strengths
14.3. Weaknesses
14.4. Opportunities
14.5. Threats
15. Value Chain Analysis
16. Porters Five Forces Analysis
16.1. Overview
16.2. Bargaining Power of Buyers
16.3. Bargaining Power of Suppliers
16.4. Degree of Competition
16.5. Threat of New Entrants
16.6. Threat of Substitutes
17. Price Analysis
18. Competitive Landscape
18.1. Market Structure
18.2. Key Players
18.3. Profiles of Key Players
18.3.1. Ajinomoto Bio-Pharma Services Company Overview Product Portfolio Financials SWOT Analysis
18.3.2. BioSpring
18.3.3. CliniSciences
18.3.4. CMIC Group
18.3.5. Halo-Bio RNAi Therapeutics
18.3.6. LGC Biosearch Technologies
18.3.7. NeoNeuro
18.3.8. New England Biolabs
18.3.9. Nitto Denko Avecia
18.3.10. NOXXON Pharma
19. Research Methodology

Frequently Asked Questions:

What is the current size of the Aptamers Therapeutics Technologies and Services Market?

The market is projected to grow from USD 423.33 million in 2024.

What factors are driving the growth of the Aptamers Therapeutics Technologies and Services Market?

Key drivers include the advantages of aptamers over traditional therapeutics, expanding application areas in medicine, advancements in aptamer technology, and growing investment and research activities.

What are the key segments within the Aptamers Therapeutics Technologies and Services Market?

The market is segmented by application area into therapeutics, research, and diagnostics; by type of aptamer into DNA, RNA, and peptide; and other segments include target indication, route of administration, scale of operation, focus area, and company size.

What are some challenges faced by the Aptamers Therapeutics Technologies and Services Market?

Challenges include the high cost of development, regulatory uncertainties, manufacturing challenges, limited clinical data, complex intellectual property landscape, and competition from established therapies.

Who are the major players in the Aptamers Therapeutics Technologies and Services Market?

Major players include Ajinomoto Bio-Pharma Services, New England Biolabs, Nitto Denko Avecia, and other key companies such as BioSpring and CliniSciences.

Which segment is leading the market share?

The therapeutic segment is leading the market share due to its wide application in developing drugs for various diseases, coupled with high investment in this area.

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