Optogenetics: Market Growth, Future Prospects and Competitive Analysis, 2016 - 2022
The general concept of Optogenetics refers to the use of different genetically encoded probes for in vivo optical stimulation for studying neuroscience. Optogenetics is the emerging field of biotechnology that combines optical with genetic engineering to observe, analyze and control physiological functions in animal brain. Extensive research on optogenetics is being conducted in the fields of neuroscience, ophthalmology, cardiology, behavioral science and others.
This report studies the global optogenetics market on the basis of sensors, actuators, targeting techniques, applications and geography. Market size and forecast for each level of segmentation is being provided in this report for the period 2014-2022 with respective compounded annual growth rates (CAGR) for the forecast period 2016-2022. Based on sensors used, this market is studied for voltage-sensitive fluorescent proteins, genetically encoded calcium indicators, chloride sensors, pH sensors and neurotransmitter release sensors. Channelrhodopsin, Halorhodopsin and Archaerhodopsin are the actuators/effectors studied. The targeting techniques for optogenetics considered in this report include transgenic animals, viral vectors and cre-dependant expression system. Optogenetics finds application in neuroscience, behavioral tracking, retinal disease treatment and cardioversion and pacing.
Geographically, the optogenetics market is studied for the following regional markets:
Market size and forecast for these each regional are presented in this study for the period 2014-2022. Market growth rates for the forecast period 2016-2022 are also included in this report, considering 2015 as the base year.
Along with market estimation, qualitative information and assessment tools which are provided in the report depict better analysis of current market scenario and future trends. Data points such as drivers, restrains, and opportunities provide information related to current market dynamics influencing the market. The report also provides information on most attractive market during the forecast period along with competitive landscape of major players participating in the market. This report concludes with company profiles section that highlights major information about the key players engaged in optogenetics market.
Chapter 1 Preface
1.1 Report Description
1.2 Market Segmentation
1.3 Research Methodology
Chapter 2 Executive Summary
2.1 Optogenetics Market, by Sensors, 2015 (USD Mn)
2.2 Optogenetics Market Share, by Actuators/Effectors, 2015 (Value %)
2.3 Optogenetics Market, by Targeting Technique, 2015 (USD Mn)
2.4 Optogenetics Market, by Applications, 2015 (USD Mn)
2.5 Optogenetics Market Share, by Geography, 2015 (Value %)
Chapter 3 Optogenetics: Market Dynamics and Outlook
3.1 Introduction, Facts and Figures
3.2 Drivers
3.3 Challenges
3.4 Opportunities
3.5 Major Commercial Events
3.6 Purchase Factors Assessment
3.7 Recent Patent Development
3.8 Attractive Investment Proposition
3.9 Competitive Analysis: Optogenetics, by Key Market Players
Chapter 4 Global Optogenetics Market, by Sensors
4.1 Preface
4.2 Voltage-Sensitive Fluorescent Proteins
4.3 Genetically Encoded Calcium Indicators
4.4 Chloride Sensors
4.5 pH Sensors
4.6 Neurotransmitter Release Sensors
Chapter 5 Global Optogenetics Market, by Actuators/Effectors
5.1 Preface
5.2 Channelrhodopsin (ChR)
5.3 Halorhodopsin (NpHR)
5.4 Archaerhodopsin (Arch)
Chapter 6 Global Optogenetics Market, by Targeting Technique
6.1 Preface
6.2 Transgenic Animals
6.3 Viral Vectors
6.4 Cre-Dependant Expression System
Chapter 7 Global Optogenetics Market, by Applications
7.1 Preface
7.2 Neuroscience
7.3 Behavioral Tracking
7.4 Retinal Disease Treatment
7.1 Cardioversion and Pacing
Chapter 8 Global Optogenetics Market, by Geography
8.1 Preface
8.2 North America
8.3 Europe
8.4 Asia-Pacific
8.5 Latin America
8.6 Middle East and Africa (MEA)
Chapter 9 Company Profiles
9.1 Thomas RECORDING GmbH
9.1.1 Business Description
9.1.2 Financial Health and Budget Allocation
9.1.3 Product Positions/Portfolio
9.1.4 News Coverage
9.2 Thorlabs
9.2.1 Business Description
9.2.2 Financial Health and Budget Allocation
9.2.3 Product Positions/Portfolio
9.2.4 News Coverage
9.3 Noldus
9.3.1 Business Description
9.3.2 Financial Health and Budget Allocation
9.3.3 Product Positions/Portfolio
9.3.4 News Coverage
9.4 Bruker
9.4.1 Business Description
9.4.2 Financial Health and Budget Allocation
9.4.3 Product Positions/Portfolio
9.4.4 News Coverage
9.5 Addgene
9.5.1 Business Description
9.5.2 Financial Health and Budget Allocation
9.5.3 Product Positions/Portfolio
9.5.4 News Coverage
9.6 Coherent, Inc.
9.6.1 Business Description
9.6.2 Financial Health and Budget Allocation
9.6.3 Product Positions/Portfolio
9.6.4 News Coverage
9.7 Cobalt, Inc.
9.7.1 Business Description
9.7.2 Financial Health and Budget Allocation
9.7.3 Product Positions/Portfolio
9.7.4 News Coverage
9.8 Regenxbio, Inc.
9.8.1 Business Description
9.8.2 Financial Health and Budget Allocation
9.8.3 Product Positions/Portfolio
9.8.4 News Coverage
9.9 Scientifica
9.9.1 Business Description
9.9.2 Financial Health and Budget Allocation
9.9.3 Product Positions/Portfolio
9.9.4 News Coverage
9.10 Gensight
9.10.1 Business Description
9.10.2 Financial Health and Budget Allocation
9.10.3 Product Positions/Portfolio
9.10.4 News Coverage
9.11 Other Notable Players
List Of Table :
TABLE 1 Global Optogenetics Market, by Sensors, 2014 – 2022 (USD Mn)
TABLE 2 Global Optogenetics Market, by Actuators/Effectors, 2014 – 2022 (USD Mn)
TABLE 3 Global Optogenetics Market, by Targeting Technique, 2014 – 2022 (USD Mn)
TABLE 4 Global Optogenetics Market, by Applications, 2014 – 2022 (USD Mn)
TABLE 5 Global Optogenetics Market, by Geography, 2014 – 2022 (USD Mn)
List Of Figure :
FIG. 1 Optogenetics: Market Segmentation
FIG. 2 Optogenetics Market, by Sensors, 2015 (USD Mn)
FIG. 3 Optogenetics Market Share, by Actuators/Effectors, 2015 (Value %)
FIG. 4 Optogenetics Market, by Targeting Technique, 2015 (USD Mn)
FIG. 5 Optogenetics Market, by Applications, 2015 (USD Mn)
FIG. 6 Optogenetics Market Share, by Geography, 2015 (Value %)
FIG. 7 Attractive Investment Proposition, Optogenetics Market, 2015
FIG. 8 Competitive Analysis: Optogenetics, by Key Market Players
FIG. 9 Global Voltage-Sensitive Fluorescent Proteins Market, 2014 – 2022 (USD Mn)
FIG. 10 Global Genetically Encoded Calcium Indicators Market, 2014 – 2022 (USD Mn)
FIG. 11 Global Chloride Sensors Market, 2014 – 2022 (USD Mn)
FIG. 12 Global pH Sensors Market, 2014 – 2022 (USD Mn)
FIG. 13 Global Neurotransmitter Release Sensors Market, 2014 – 2022 (USD Mn)
FIG. 14 Global Channelrhodopsin Optogenetics Market, 2014 – 2022 (USD Mn)
FIG. 15 Global Halorhodopsin Optogenetics Market, 2014 – 2022 (USD Mn)
FIG. 16 Global Archaerhodopsin Optogenetics Market, 2014 – 2022 (USD Mn)
FIG. 17 Global Optogenetics with Transgenic Animals Market, 2014 – 2022 (USD Mn)
FIG. 18 Global Optogenetics with Viral Vectors Market, 2014 – 2022 (USD Mn)
FIG. 19 Global Optogenetics with Cre-Dependant Expression System Market, 2014 – 2022 (USD Mn)
FIG. 20 Global Optogenetics in Neuroscience Market, 2014 – 2022 (USD Mn)
FIG. 21 Global Optogenetics in Behavioral Tracking Market, 2014 – 2022 (USD Mn)
FIG. 22 Global Optogenetics in Retinal Disease Treatment Market, 2014 – 2022 (USD Mn)
FIG. 23 Global Optogenetics in Cardioversion and Pacing Market, 2014 – 2022 (USD Mn)
FIG. 24 North America Optogenetics Market, by Country, 2014 – 2022 (USD Mn)
FIG. 25 Europe Optogenetics Market, 2014 – 2022 (USD Mn)
FIG. 26 Asia-Pacific Optogenetics Market, 2014 – 2022 (USD Mn)
FIG. 27 Latin America Optogenetics Market, 2014 – 2022 (USD Mn)
FIG. 28 Middle East and Africa Optogenetics Market, 2014 – 2022 (USD Mn)
Based on the type of targeting techniques, the global optogenetics market is categorized into:
Genetic targeting is a critical feature of optogenetics, which facilitates us to explore neurons at better resolution. Use of trans-synaptic trafficking has given us a novel technique with possibility to target specific axonal branches. Transgenic animals demonstrate uniform expression level. However, production of transgenic line is tedious effort and time consuming. Unlike transgenic animals that are restricted to rats and mice models viral vectors can be successfully used in higher organisms. Moreover, viral vectors is that these agents take short time to achieve transgene expression. As against transgenic animals, higher levels of transgene expression can be acquired by increasing transgene copy number. An issue with using viral vectors is that certain cell-type specific promoters exhibit weak expression levels. This drawback can be overcome with Cre-dependant expression system, which have a strong Cre-dependant promoter.
Based on the type actuators/effectors, the global optogenetics market is segmented as follows:
The discovery of NpHR and ChR2 and their potential application in neuroscience have created a surge in optogenetic research. Light-induced effectors allow for control of neural circuits at millisecond level. Such high temporal resolution of ChR2 and NpHR makes them a potential research tool. ChR2 and NpHR are stimulated by different light wavelengths, which allows the two tools to be used together to control neural activity as per requirement. ChR2 is calcium permeable and as calcium influx is linked with neurotransmitter release, light induced reaction have a high chance of neurotransmitter release. ChR2 has been demonstrated to be useful in Parkinson’s disease treatment (linked with safety in with respect to long-term expression of ChR2). Much work needs to be done to determine safety of ChR2 expression in humans. Though several innovations in the field of optogenetic effectors have taken place in the past few years, the trend is further speeding up. This is still an early technology and further breakthroughs in this market are anticipated.
Based on the type of sensors, the global optogenetics market is subdivided as follows:
VSFPs are expressed by cells, thus this allows them advantage from genetic targeting perspective. Initially, voltage-sensitive dyes were used for visualization of voltage changes, however, localized expression was difficult to achieve. VSFPs have higher precision compared to its precursors. Yet, there is very limited data available demonstrating the benefits of use of VSFPs. VSFPs are opined to have come to a stage where their potential will be effectively harnessed. A basic issue with using calcium levels as a parameter for action potentials is that some cellular processes use alteration of Ca2+levels. Hence, no matter how precise and sensitive GECIs are made, they still possess a risk of overestimating action potential. GECIs have been successfully used for assessment of synaptic and spiking activity across neurons. Further evolution in this field will increase information about mechanism of synaptic circuits.
For the purpose of this study, the global optogenetics market is categorized as follows:
North America and particularly United States is the largest market for optogenetics. Large-scale neuroscience and optogenetic research activities being conducted in North America. Optogenetics in North America is anticipated to follow the overall biotechnology market trends in the region. Europe is second in lead in terms of regional revenue. High awareness and breakthrough research activities being conducted in this region by both academic institutions and related companies. Asia-Pacific, Latin America and Middle East and Africa are still in the adoption stage of this technology. However, among these regions, Asia-Pacific is estimated to be the fastest developing regional market. Large-scale CRO activities being conducted in the region also allow the growth of Asia-Pacific optogenetics market.
