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Recombinant Plasma Protein Therapeutics Market By Drug Class (Recombinant Factor VIII and Recombinant Factor IX), By Cell Line (Chinese Hamster Ovary, Baby Hamster Kidney and Human Embryonic Kidney and Other), By Indication (Hemophilia A, Hemophilia B, Von Willebrand Disease and Other) – Growth, Future Prospects & Competitive Analysis, 2018 – 2026

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Published: | Report ID: 9118 | Report Format : PDF

Market Insights

The recombinant plasma protein therapeutics market is set to grow from US$ 7,788.9 million in 2017 to US$ 15,910.5 million in 2026, expanding at an annual growth rate of 8.3% during the forecast period from 2018 to 2026. According to the World Federation of Hemophilia (WFH), approximately 1 in 1,000 people worldwide suffer from some form of a bleeding disorder, and 75% of them receive inadequate treatment or remain undiagnosed.

Market Synopsis

Recombinant coagulation factor VIII is becoming more popular in the treatment of hemophilia A due to its lack of bloodborne transmission disease and less severe side effects when compared to desmopressin.

Recombinant coagulation factor VIII is leading the drug class segment for the recombinant plasma protein therapeutics market. It is preferred over human plasma-derived products to avoid the potential transmission of bloodborne infections. It is replacing desmopressin in treating mild hemophilia due to its fewer adverse effects. Recombinant factor IX will gain growth momentum in the near future owing to the recent FDA approval of Rebinyn (Novo Nordisk) for the long-term treatment of hemophilia B.

Design Element 2

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CTA Design Element 3

The ability to adapt growth conditions in serum-free suspension, a powerful gene amplification system and the capacity for post-translational modification drive the Chinese hamster ovary cell lines in recombinant protein synthesis.

Over the last two decades, Chinese hamster ovarian cell lines have gained immense popularity over other cell lines, such as baby hamster kidney cell lines and human embryonic kidney cell lines. Its ability to adapt to serum-free suspension growth conditions, perform powerful gene amplifications, and undergo post-translational modification distinguishes it as the most demanding cell line in recombinant protein synthesis.

high prevalence rate, with 70% of diagnosed patients having a severe form of hemophilia, market growth

Hemophilia A, also known as clotting factor VIII deficiency or classical hemophilia, is currently leading the indication segment for the recombinant plasma protein therapeutics market. It has a high prevalence rate of 1 in 5000 people, with approximately 70% of diagnosed patients reported to be suffering from a severe form of hemophilia A.

The other type is hemophilia B, which is a less common form with an occurrence rate of 1 in 25,000 people and is caused by a lack of clotting factor IX. Von Willebrand disease is keen to register impressive growth in the near future due to its high occurrence in blood group O and rising public health awareness.

The rising prevalence of hemophilia A and the presence of a comprehensive network of federally funded treatment centers for hemophilia drive market growth in North America.

North America reigns over the regional segment of the recombinant plasma protein therapeutics market with a share of 40%. The chief factors controlling its market growth are the rising prevalence of hemophilia A. According to the research findings of the Centers for Disease Control and Prevention (CDC), approximately 20,000 people are suffering from hemophilia in the United States.

The existence of a comprehensive network of federally funded treatment centers for hemophilia caters to the medical needs of 70% of patients with blood clotting disorders in the North American region. Due to the increasing number of newborns with hemophilia, Europe accounts for 30% of the market share. According to European Medical Agency (EMA) research findings, 400 babies are born with hemophilia each year.

The presence of major players such as Novo Nordisk A/S, Bayer AG, Shire Plc, and others in Europe boosts the market growth. Asia Pacific holds 20% market growth and is keen to register rapid growth during the forecast period owing to the adoption of recombinant technology for protein synthesis and a large patient pool suffering from blood clotting disorders.

Periods of History and Forecast

This research report presents the analysis of each segment from 2016 to 2026, considering 2017 as the base year for the research. The compound annual growth rate (CAGR) for each of the respective segments is calculated for the forecast period from 2018 to 2026.

Report Scope by Segments

Recombinant plasma protein therapeutics market segmentation is as follows:

Biotechnology companies manufacturing recombinant plasma proteins are Aptevo Therapeutics, Bayer AG, Bioverativ Therapeutics, Inc., CSL Behring, Novo Nordisk A/S, Octapharma, Plc., Pfizer, Inc., Pharming Group NV, Shire, Plc., and Viropharma Biologics, Inc.

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Key questions are answered in this report.

  • Which biotechnology companies are manufacturing recombinant coagulation factors?
  • Why are recombinant coagulation factors replacing human plasma-derived proteins and desmopressin in treating hemophilia A?
  • What is the disease etiology and treatment regimen for Von Willebrand’s disease?
  • Which factors make the Chinese hamster ovary the most popular cell line in comparison to other cell lines?
  • What will be the market trend in the developed and developing nations during the forecast period concerning the market growth of recombinant plasma protein therapeutics?

Chapter 1. Preface
1.1. Report Scope and Description
1.1.1. Purpose of the Report
1.1.2. Target Audience
1.1.3. USP and Key Offerings
1.2. Research Scope
1.3. Research Methodology
1.3.1. Phase I-Secondary Research
1.3.2. Phase II-Primary Research
1.3.3. Approach Adopted
1.3.4. Top-down Approach
1.3.5. Bottom-up Approach
1.3.6. Phase III-Expert Panel Review
1.3.7. Assumptions
1.4. Market Segmentation

Chapter 2. Executive Summary
2.1. Global RPPT Market Portraiture
2.2. Global RPPT Market, by Drug Class, 2017 (US$ Mn)
2.3. Global RPPT Market, by Cell Line, 2017 (US$ Mn)
2.4. Global RPPT Market, by Indication, 2017 (US$ Mn)
2.5. Global RPPT Market, by Geography, 2017 (US$ Mn)

Chapter 3. Recombinant Plasma Protein Therapeutics (RPPT) Market: Dynamics and Future Outlook
3.1. Market Overview
3.2. Drivers
3.3. Challenges
3.4. Opportunities
3.5. Attractive Investment Proposition, by Geography, 2017
3.6. Competitive Analysis: Global RPPT Market, by Key Players, 2017

Chapter 4. Global Recombinant Plasma Protein Therapeutics (RPPT) Market, by Drug Class
4.1. Overview
4.2. Recombinant Factor VIII
4.3. Recombinant Factor IX

Chapter 5. Global Recombinant Plasma Protein Therapeutics (RPPT) Market, by Cell Line
5.1. Overview
5.2. Chinese Hamster Ovary
5.3. Baby Hamster Kidney
5.4. Human Embryonic Kidney
5.5. Others

Chapter 6. Global Recombinant Plasma Protein Therapeutics (RPPT) Market, by Indication
6.1. Overview
6.2. Hemophilia A
6.3. Hemophilia B
6.4. Von Willebrand Disease
6.5. Others

Chapter 7. Global Recombinant Plasma Protein Therapeutics (RPPT) Market, by Geography
7.1. Overview
7.2. North America RPPT Market Analysis, 2016 – 2026
7.2.1. North America RPPT Market, by Drug Class, 2016 – 2026 (US$ Mn)
7.2.2. North America RPPT Market, by Cell Line, 2016 – 2026 (US$ Mn)
7.2.3. North America RPPT Market, by Indication, 2016 – 2026 (US$ Mn)
7.2.4. North America RPPT Market, by Country, 2016 – 2026 (US$ Mn)
7.2.4.1. U.S.
7.2.4.2. Canada
7.3. Europe RPPT Market Analysis, 2016 – 2026
7.3.1. Europe RPPT Market, by Drug Class, 2016 – 2026 (US$ Mn)
7.3.2. Europe RPPT Market, by Cell Line, 2016 – 2026 (US$ Mn)
7.3.3. Europe RPPT Market, by Indication, 2016 – 2026 (US$ Mn)
7.3.4. Europe RPPT Market, by Country/Region, 2016 – 2026 (US$ Mn)
7.3.4.1. U.K.
7.3.4.2. Germany
7.3.4.3. Rest of Europe
7.4. Asia Pacific RPPT Market Analysis, 2016 – 2026
7.4.1. Asia Pacific RPPT Market, by Drug Class, 2016 – 2026 (US$ Mn)
7.4.2. Asia Pacific RPPT Market, by Cell Line, 2016 – 2026 (US$ Mn)
7.4.3. Asia Pacific RPPT Market, by Indication, 2016 – 2026 (US$ Mn)
7.4.4. Asia Pacific RPPT Market, by Country/Region, 2016 – 2026 (US$ Mn)
7.4.4.1. China
7.4.4.2. Japan
7.4.4.3. Rest of Asia Pacific
7.5. Latin America RPPT Market Analysis, 2016 – 2026
7.5.1. Latin America RPPT Market, by Drug Class, 2016 – 2026 (US$ Mn)
7.5.2. Latin America RPPT Market, by Cell Line, 2016 – 2026 (US$ Mn)
7.5.3. Latin America RPPT Market, by Indication, 2016 – 2026 (US$ Mn)
7.5.4. Latin America RPPT Market, by Country/Region, 2016 – 2026 (US$ Mn)
7.5.4.1. Brazil
7.5.4.2. Mexico
7.5.4.3. Rest of Latin America
7.6. Middle East and Africa RPPT Market Analysis, 2016 – 2026
7.6.1. MEA RPPT Market, by Drug Class, 2016 – 2026 (US$ Mn)
7.6.2. MEA RPPT Market, by Cell Line, 2016 – 2026 (US$ Mn)
7.6.3. MEA RPPT Market, by Indication, 2016 – 2026 (US$ Mn)
7.6.4. MEA RPPT Market, by Country/Region, 2016 – 2026 (US$ Mn)
7.6.4.1. GCC
7.6.4.2. Rest of MEA

Chapter 8. Company Profiles
8.1. Aptevo Therapeutics.
8.1.1. Business Description
8.1.2. Financial Information (Subject to data availability)
8.1.3. Product Portfolio
8.1.4. News Coverage
8.2. Bayer AG
8.3. Bioverativ Therapeutics, Inc.
8.4. CSL Behring
8.5. Novo Nordisk A/S
8.6. Octapharma, Plc.
8.7. Pfizer, Inc.
8.8. Pharming Group NV
8.9. Shire, Plc.
8.10. Viropharma Biologics, Inc.

List of Figures

FIG. 1 Recombinant Plasma Protein Therapeutics (RPPT) Market: Research Methodology
FIG. 2 RPPT: Market Segmentation
FIG. 3 Global RPPT Market, by Drug Class, 2017 (US$ Mn)
FIG. 4 Global RPPT Market, by Cell Line, 2017 (US$ Mn)
FIG. 5 Global RPPT Market, by Indication, 2017 (US$ Mn)
FIG. 6 Global RPPT Market, by Geography, 2017 (US$ Mn)
FIG. 7 Attractive Investment Proposition: by Geography, 2017
FIG. 8 Competitive Analysis: Global RPPT Market, by Key Players, 2017
FIG. 9 Global Recombinant Factor VIII Market for RPPT, 2016 – 2026 (US$ Mn)
FIG. 10 Global Recombinant Factor IX Market for RPPT, 2016 – 2026 (US$ Mn)
FIG. 11 Global Chinese Hamster Ovary Market for RPPT, 2016 – 2026 (US$ Mn)
FIG. 12 Global Baby Hamster Kidney Market for RPPT, 2016 – 2026 (US$ Mn)
FIG. 13 Global Human Embryonic Kidney for Market for RPPT, 2016 – 2026 (US$ Mn)
FIG. 14 Global Other Cell Lines Market for RPPT, 2016 – 2026 (US$ Mn)
FIG. 15 Global Hemophilia A Market for RPPT, 2016 – 2026 (US$ Mn)
FIG. 16 Global Hemophilia B Market for RPPT, 2016 – 2026 (US$ Mn)
FIG. 17 Global Von Willebrand Disease Market for RPPT, 2016 – 2026 (US$ Mn)
FIG. 18 Global Other Indications Market for RPPT, 2016 – 2026 (US$ Mn)
FIG. 19 U.S. RPPT Market, 2016 – 2026 (US$ Mn)
FIG. 20 Canada RPPT Market, 2016 – 2026 (US$ Mn)
FIG. 21 U.K. RPPT Market, 2016 – 2026 (US$ Mn)
FIG. 22 Germany RPPT Market, 2016 – 2026 (US$ Mn)
FIG. 23 Rest of Europe RPPT Market, 2016 – 2026 (US$ Mn)
FIG. 24 China RPPT Market, 2016 – 2026 (US$ Mn)
FIG. 25 Japan RPPT Market, 2016 – 2026 (US$ Mn)
FIG. 26 Rest of Asia Pacific RPPT Market, 2016 – 2026 (US$ Mn)
FIG. 27 Brazil RPPT Market, 2016 – 2026 (US$ Mn)
FIG. 28 Mexico RPPT Market, 2016 – 2026 (US$ Mn)
FIG. 29 Rest of Latin America RPPT Market, 2016 – 2026 (US$ Mn)
FIG. 30 GCC RPPT Market, 2016 – 2026 (US$ Mn)
FIG. 31 Rest of MEA RPPT Market, 2016 – 2026 (US$ Mn)

List of Tables

TABLE 1 Global Recombinant Plasma Protein Therapeutics (RPPT) Market Portraiture
TABLE 2 Global RPPT Market, by Drug Class, 2016 – 2026 (US$ Mn)
TABLE 3 Global RPPT Market, by Cell Line, 2016 – 2026 (US$ Mn)
TABLE 4 Global RPPT Market , by Indication, 2016 – 2026 (US$ Mn)
TABLE 5 Global RPPT Market, by Geography, 2016 – 2026 (US$ Mn)
TABLE 6 North America RPPT Market, by Drug Class, 2016 – 2026 (US$ Mn)
TABLE 7 North America RPPT Market, by Cell Line, 2016 – 2026 (US$ Mn)
TABLE 8 North America RPPT Market, by Indication, 2016 – 2026 (US$ Mn)
TABLE 9 North America RPPT Market, by Country, 2016 – 2026 (US$ Mn)
TABLE 10 Europe RPPT Market, by Drug Class, 2016 – 2026 (US$ Mn)
TABLE 11 Europe RPPT Market, by Cell Line, 2016 – 2026 (US$ Mn)
TABLE 12 Europe RPPT Market, by Indication, 2016 – 2026 (US$ Mn)
TABLE 13 Europe RPPT Market, by Country/Region, 2016 – 2026 (US$ Mn)
TABLE 14 Asia Pacific RPPT Market, by Drug Class, 2016 – 2026 (US$ Mn)
TABLE 15 Asia Pacific RPPT Market, by Cell Line, 2016 – 2026 (US$ Mn)
TABLE 16 Asia Pacific RPPT Market, by Indication, 2016 – 2026 (US$ Mn)
TABLE 17 Asia Pacific RPPT Market, by Country/Region, 2016 – 2026 (US$ Mn)
TABLE 18 Latin America RPPT Market, by Drug Class, 2016 – 2026 (US$ Mn)
TABLE 19 Latin America RPPT Market, by Cell Line, 2016 – 2026 (US$ Mn)
TABLE 20 Latin America RPPT Market, by Indication, 2016 – 2026 (US$ Mn)
TABLE 21 Latin America RPPT Market, by Country/Region, 2016 – 2026 (US$ Mn)
TABLE 22 Middle East and Africa RPPT Market, by Drug Class, 2016 – 2026 (US$ Mn)
TABLE 23 Middle East and Africa RPPT Market, by Cell Line, 2016 – 2026 (US$ Mn)
TABLE 24 Middle East and Africa RPPT Market, by Indication, 2016 – 2026 (US$ Mn)
TABLE 25 Middle East and Africa RPPT Market, by Country/Region, 2016 – 2026 (US$ Mn)
TABLE 26 Aptevo Therapeutics: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 27 Bayer AG: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 28 Bioverativ Therapeutics, Inc.: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 29 CSL Behring: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 30 Novo Nordisk A/S: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 31 Octapharma, Plc.: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 32 Pfizer, Inc.: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 33 Pharming Group NV: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 34 Shire, Plc.: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 35 Viropharma Biologics, Inc.: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)

Frequently Asked Question

What is the size of Recombinant Plasma Protein Therapeutics Market?

The market for Recombinant Plasma Protein Therapeutics Market is expected to reach USD$ 15,910.5 Mn in 2026

What is the Recombinant Plasma Protein Therapeutics Market CAGR?

The Recombinant Plasma Protein Therapeutics Market is expected to see significant CAGR growth over the coming years, at 8.3%.

What is the Forecast period considered for Recombinant Plasma Protein Therapeutics Market?

The report is forecasted from 2018 -2026.

What is the base year considered for Recombinant Plasma Protein Therapeutics Market?

The base year of this report is 2017.

Who are the major players in this market?

Bayer AG, Bioverativ Therapeutics, Inc., CSL Behring, Novo Nordisk A/S, Octapharma, Plc., Pfizer, Inc., Pharming Group NV, Shire, Plc. are some of the major players in the global market.

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