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Lung Cancer Therapeutics Market By Cancer Cell Type (Small Lung Cancer, Non-Small Lung Cancer (NSLC)); By Molecule Type (Biologics, Small Molecules); By Mode of Administration (Injectable, Oral); By Type (AML, CML, ALL, CLL); By Region – Growth, Share, Opportunities & Competitive Analysis, 2024 – 2032

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Published: | Report ID: 38769 | Report Format : PDF
REPORT ATTRIBUTE DETAILS
Historical Period  2019-2022
Base Year  2023
Forecast Period  2024-2032
Lung Cancer Therapeutics Market Size 2023  USD 23892.4 Million
Lung Cancer Therapeutics Market, CAGR  12.70%
Lung Cancer Therapeutics Market Size 2032  USD 71,127.22 Million

Market Overview:

The lung cancer therapeutics market is expected to reach USD 71,127.22 million by 2032, reflecting a compound annual growth rate (CAGR) of 12.70% in 2023.

The lung cancer therapeutics market is experiencing significant evolution driven by key trends and market drivers. Advancements in personalized medicine and the development of targeted therapies are enhancing treatment efficacy while minimizing side effects. Immunotherapy drugs are revolutionizing treatment options by leveraging the body’s immune system to combat cancer cells. Additionally, combination therapies, integrating different treatment modalities, show promise in improving patient outcomes. There’s also a growing emphasis on early detection, facilitated by increased awareness and advancements in screening technologies. Market growth is further propelled by factors such as the aging global population, high smoking rates in certain regions, rising cancer awareness, and favorable regulatory environments, which streamline drug development and market access.

Geographically, the market demonstrates diversity, with North America currently leading due to advanced healthcare infrastructure and rapid technology adoption. Europe follows closely, benefiting from a robust healthcare system and innovation focus, albeit with slightly delayed regulatory processes. The Asia-Pacific region is poised for rapid growth, driven by its large and aging population, rising disposable income, and increasing healthcare investments. Meanwhile, the Rest of the World segment, encompassing regions like Latin America and the Middle East, is expected to grow steadily as healthcare infrastructure improves and access to advanced therapies increases. In this competitive landscape, major players like F. Hoffmann-La Roche Ltd., Streneca plc, Bristol-Myers Squibb Company, and others vie for market dominance alongside emerging pharmaceutical companies, fostering innovation and driving advancements in lung cancer therapeutics.

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Market Drivers:

Rising Prevalence and Mortality Rates:

Lung cancer remains the most common cause of cancer-related deaths globally. According to GLOBOCAN 2020, lung cancer accounted for roughly 11.4% of all new cancer diagnoses and 18.0% of cancer-related deaths. This translates to approximately 2.2 million new cases and 1.8 million deaths in 2020. For instance, in the United States alone, there were an estimated 235,760 new cases of lung cancer and 131,880 deaths from the disease in 2021. This alarming burden of disease is a major impetus for the development and adoption of novel and effective lung cancer therapies.

Growing Geriatric Population and Increased Smoking Rates:

The global population is aging rapidly, with a significant rise in the elderly demographic, who are more susceptible to lung cancer. The number of people aged 60 years and older is projected to nearly double from 12% in 2015 to around 22% by 2050. For instance, in Japan, one of the countries with the highest proportion of elderly people, the percentage of the population aged 65 and over was 28.4% in 2020. This aging population is more susceptible to lung cancer. Furthermore, tobacco use is increasing, particularly in developing countries. In 2020, 22.3% of the world’s population used tobacco: 36.7% of men and 7.8% of women. For instance, in Indonesia, the smoking rate among men was as high as 76.2% in 2019. This trend is contributing to the growing number of lung cancer cases and increasing the demand for effective treatments.

Technological Advancements and Treatment Diversification:

Medical technology is advancing rapidly, leading to the development of innovative lung cancer treatments. For example, the use of targeted therapies has increased survival rates by 30%. Immunotherapies have shown promise, with some studies reporting a doubling of survival times. Advances in surgical techniques and radiation therapy have also improved patient outcomes. These diverse treatment options allow for personalized treatment plans based on individual patient needs and disease characteristics, potentially improving outcomes.

Rising Focus on Early Diagnosis and Increased Treatment Accessibility:

Growing awareness of early detection methods and advancements in diagnostic tools are enabling earlier identification of lung cancer. This early intervention allows for more effective treatment and potentially improves the patient’s prognosis. Additionally, initiatives aimed at increasing access to healthcare services and lung cancer treatments in developing regions are expected to contribute to market growth.

Market Trends:

Rising Demand for Targeted Therapies and Immunotherapy:

Advancements in genomics and personalized medicine are leading to the development of targeted therapies that focus on specific genetic mutations driving lung cancer growth. For instance, a review published in July 2023 highlighted the recent advances in molecular biology and immunology that have enabled the development of highly targeted therapies for many forms of breast cancer. This shift towards targeted therapies offers the potential for improved treatment efficacy and reduced side effects compared to traditional chemotherapy. Immunotherapy, which harnesses the body’s immune system to fight cancer cells, is also experiencing a surge in popularity. Checkpoint inhibitors, a type of immunotherapy, have shown promising results in treating lung cancer, and the development of new and more specific immunotherapies is ongoing. For example, the FDA has already approved some immune-checkpoint blockers in combination with chemotherapeutic drugs to treat triple-negative breast cancer (TNBC), and several trials are ongoing. This focus on targeted and immune-based therapies is expected to be a major driver of market growth.

Increasing Focus on Early Detection and Screening:

Growing awareness of early detection strategies for lung cancer is leading to an increase in diagnosed cases. This, in turn, is driving demand for therapeutic interventions. Technological advancements in early detection methods, such as low-dose CT scans, are facilitating the identification of lung cancer at earlier stages, when treatment is often more successful. For example, a study published in April 2023 identified seven differentially methylated genes (DMGs) that were highly associated with lung cancer. Based on this, a new diagnostic model was developed, termed the “7-DMR model,” which achieved high accuracy in distinguishing lung cancers from benign diseases. Additionally, the aging population is another factor contributing to the rise in lung cancer diagnoses. As the population ages, the risk of developing lung cancer increases, further fueling the demand for effective treatment options. For instance, lung cancer is a disease of older adults with a median age of 71 years at diagnosis; over two-thirds of men and women diagnosed with lung cancer are above age 65, with over a quarter over age 75. This trend is expected to continue as the population continues to age, leading to an increased demand for effective lung cancer treatments.

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Market Challenge Analysis:

High Cost of Treatment:

Lung cancer treatment regimens often involve a combination of therapies, leading to significant financial burdens on patients and healthcare systems. The high cost of novel targeted therapies and immunotherapies, while demonstrating improved efficacy, can limit patient access and restrict widespread adoption. Additionally, managing and controlling healthcare costs associated with these treatments will be crucial for market sustainability.

Limited Early Detection and Drug Resistance:

Early detection of lung cancer remains a challenge, often leading to diagnosis at later stages when treatment options are limited. Furthermore, the emergence of drug resistance can hinder the effectiveness of existing therapies, necessitating the development of new treatment strategies to overcome these resistances and improve long-term patient outcomes. Addressing these challenges will require advancements in screening methods, as well as continuous research and development of novel therapeutic approaches to combat drug resistance.

Segmentation Analysis:

By Cancer Cell Type:

Lung cancer comprises two main types: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). NSCLC is the predominant form, constituting approximately 80–85% of all cases. It encompasses various histological subtypes, with adenocarcinoma and squamous cell carcinoma being the most prevalent. Adenocarcinoma typically originates in the peripheral lung tissue and is more common in non-smokers, while squamous cell carcinoma usually develops in the central airways and is associated with a history of smoking. On the other hand, SCLC, although less prevalent, is known for its aggressive nature. It tends to grow and spread rapidly, making it challenging to treat, often requiring a different therapeutic approach compared to NSCLC.

By Molecule Type:

Lung cancer therapeutics encompass various treatment modalities, including small-molecule therapeutics, antibody-drug conjugates (ADCs), bispecific T-cell engagers (BiTEs), and immunotherapy checkpoint inhibitors. Small-molecule therapeutics, such as tyrosine kinase inhibitors (TKIs) and ALK inhibitors, are commonly used to target specific molecules involved in cancer cell growth and spread. ADCs combine monoclonal antibodies with cytotoxic drugs, delivering the toxic payload directly to tumor cells. BiTEs represent a newer therapy that engages the immune system’s T cells to attack cancer cells. Additionally, immunotherapy checkpoint inhibitors are designed to target immune checkpoints, enhancing the body’s ability to recognize and combat cancer cells effectively. These diverse treatment approaches offer promising avenues for the management of lung cancer, aiming to improve patient outcomes and quality of life.

Segments:

Based on cancer cell type:

  • Small Lung Cancer
  • Non-Small Lung Cancer (NSLC)

Based on Molecule Type:

  • Biologics
  • Small Molecules

Based on mode of administration:

  • Injectable
  • Oral

Based on type:

  • AML
  • CML
  • ALL
  • CLL

Based on region:

  • North America
  • Latin America
  • Europe
  • Asia Pacific
  • Middle East and Africa (MEA)

Regional Analysis:

North America:

North America holds the largest share of the global lung cancer therapeutics market, estimated to be around 40%. The United States represents the dominant market within this region, driven by factors such as advanced healthcare infrastructure, a high prevalence of lung cancer, and the presence of major pharmaceutical companies. The North American market is characterized by a strong focus on research and development, leading to the introduction of innovative therapies and targeted treatments for lung cancer. Additionally, favorable reimbursement policies and a well-established healthcare system have facilitated access to lung cancer therapeutics in this region.

Europe:

Europe accounts for a significant share of approximately 30% in the global lung cancer therapeutics market. Countries like Germany, France, the United Kingdom, and Italy are major contributors to this region’s market growth. The European market is driven by factors such as increasing lung cancer incidence rates, particularly in Western European countries, and the adoption of advanced diagnostic and treatment methods. Moreover, the region’s focus on personalized medicine and the development of targeted therapies have further boosted the lung cancer therapeutics market.

Key player:

  • Genentech (F. Hoffmann-La Roche Ltd.)
  • Eli Lilly and Company
  • Celgene Corporation
  • AstraZeneca
  • Pfizer Inc.
  • Sanofi
  • Novartis AG
  • Astellas
  • Bristol Myers Squibb
  • Boehringer-Ingelheim Pharmaceuticals, Inc.
  • Millennium Pharmaceuticals, Inc. (Takeda)
  • Merck Sharp & Dohme Corp.

Competitive Analysis:

AstraZeneca, Bristol-Myers Squibb, and Roche are dominant players in the lung cancer therapeutics market, boasting significant market shares due to their established portfolios of targeted therapies and immunotherapies. These companies prioritize research and development, continually expanding their offerings to address evolving patient needs. Pfizer and Merck & Co. also hold prominent positions with robust pipelines featuring late-stage clinical trials for innovative lung cancer therapies, particularly focusing on novel drug classes and combination therapies. Meanwhile, emerging biotechnology companies are making strides in developing targeted therapies and immunotherapies with unique mechanisms of action, challenging established players in specific market segments with their agility and niche focus.

Recent Developments:

In June 2022, Novartis received approval from the European Commission for Tabrecta for the treatment of METex14-skipping advanced non-small cell lung cancer.

In April 2022, AstraZeneca and Daiichi Sankyo received the acceptance of the supplemental Biologics License Application for Enhertu (trastuzumab deruxtecan) for the treatment of adult patients in the United States with unresectable or metastatic non-small cell lung cancer (NSCLC) by the United States FDA.

In May 2022, Cizzle Biotechnology, a diagnostics company based in the United Kingdom, inked a deal with CorePath Laboratories (“CorePath”), a full-service cancer reference laboratory, to develop and market its patented early-stage lung cancer test in the United States. There are currently no simple specialized blood tests for early detection of lung cancer where targeted treatments could enhance timely access to cancer care and save lives. However, it is estimated that over 8 million Americans are at high risk for lung cancer and should be checked annually with low-dose CT scans. A proper examination can avoid over 24,000 lung cancer deaths.

In April 2022, in conjunction with Eli Lilly and Company, NeoGenomics, Inc., which is the most prominent provider of oncology contract research services and cancer-focused genetic testing services, made an announcement of a sponsored testing program for qualifying patients with metastatic non-small cell lung cancer (NSCLC) absolutely free of charge. The NeoTYPE DNA and RNA Assay will be used by the Lilly Lung Cancer Sponsored Testing Program to grant qualifying metastatic NSCLC patients improved access to focused genomic test solutions that can assist patients and physicians in making educated treatment decisions. Eligible patients can use InVisionFirst-Lung Liquid Biopsy at no cost if findings aren’t possible due to decreased tissue input or when an invasive biopsy is prohibited medically.

Market Concentration and Characteristics:

The lung cancer therapeutics market exhibits a moderate level of concentration, characterized by a mix of established pharmaceutical giants and emerging biotechnology firms. Major players like AstraZeneca, Bristol-Myers Squibb, and Roche dominate the market with their extensive portfolios of targeted therapies and immunotherapies, leveraging their research and development capabilities to drive innovation. Alongside, smaller biotech companies are gaining traction, focusing on niche areas and offering unique treatment approaches. This competitive landscape fosters ongoing advancements in lung cancer treatment, ensuring a diverse range of therapeutic options for patients.

Report Coverage:

The research report offers an in-depth analysis based on cancer cell type, molecular type, type, and region. It details leading market players, providing an overview of their business, product offerings, investments, revenue streams, and key applications. Additionally, the report includes insights into the competitive environment, SWOT analysis, current market trends, as well as the primary drivers and constraints. Furthermore, it discusses various factors that have driven market expansion in recent years. The report also explores market dynamics, regulatory scenarios, and technological advancements that are shaping the industry. It assesses the impact of external factors and global economic changes on market growth. Lastly, it provides strategic recommendations for new entrants and established companies to navigate the complexities of the market.

Future Outlook:

  1. Tailoring treatments to specific genetic mutations and patient characteristics will improve efficacy and reduce side effects.
  2. The continued development of immune checkpoint inhibitors and other immunotherapy drugs offers promising new treatment options.
  3. The focus on targeted therapies that attack specific cancer-causing pathways is expected to lead to more effective treatments.
  4. Combining different treatment modalities, such as immunotherapy with chemotherapy or targeted therapies, is likely to become increasingly common.
  5. Advancements in screening techniques and biomarkers for early lung cancer detection will improve patient outcomes.
  6. The development of minimally invasive surgical techniques and ablation therapies will allow for more targeted and less-debilitating treatment approaches.
  7. Treatment strategies will prioritize not only survival rates but also managing side effects and improving patients’ quality of life.
  8. Increased use of companion diagnostics will help identify patients most likely to benefit from specific therapies.
  9. Real-world data analysis and the use of artificial intelligence will play a crucial role in optimizing treatment strategies and drug development.
  10. Addressing affordability concerns and ensuring equitable access to lung cancer therapies will be critical for improving global health outcomes.

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Frequently Asked Questions:

What is the current size of the lung cancer therapeutics market?

The lung cancer therapeutics market was valued at USD 23892.4 million in 2023.

What factors are driving the growth of the lung cancer therapeutics market?

The growth of the lung cancer therapeutics market is primarily driven by factors such as advancements in personalized medicine, the emergence of immunotherapy drugs, the increasing use of combination therapies, and a focus on early detection methods.

What are the key segments within the lung cancer therapeutics market?

The key segments within the lung cancer therapeutics market include small-molecule therapeutics, antibody-drug conjugates (ADCs), bispecific T-cell engagers (BiTEs), and immunotherapy checkpoint inhibitors.

What are some challenges faced by the lung cancer therapeutics market?

Some challenges faced by the Lung Cancer Therapeutics market include the high cost of treatment, the development of drug resistance, regulatory hurdles in drug approval processes, and the need for more effective treatments for small cell lung cancer (SCLC).

Who are the major players in the lung cancer therapeutics market?

The major players in the lung cancer therapeutics market include AstraZeneca, Bristol-Myers Squibb, Roche, Pfizer, Merck & Co., and several emerging biotechnology companies.

Which segment is leading the market share?

The small-molecule therapeutics segment is currently leading the market share in the lung cancer therapeutics market.

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