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Molecular Weight Markers Market By Product (DNA Markers, Protein Markers and RNA Markers), By Type (Unstained Markers, Prestained Markers and Specialty Markers), By Application (Nucleic Acid Applications and Proteomics Applications) - Growth, Future Prospects & Competitive Analysis, 2017 - 2025

Molecular weight markers are commonly known as DNA ladders, RNA ladders, or protein ladders. The main function of the molecular weight markers is to be used for the determination and identification of the molecular size of biological samples on gel electrophoresis by using the principle that molecular weight is inversely proportional to migration rate through a gel matrix. This method has undergone tremendous technological advancements and is now available in a wide range with a loading buffer in a single tube in a ready-to-use format that minimizes the time spent on thawing, diluting, and adding the tracking dye to the DNA ladder.

For the purpose of this study, the various products studied are DNA markers, protein markers, and RNA markers. DNA markers are further sub-segmented as (below 50 bp, 50 bp to 100 bp, 100 bp to 1 kb, 1 kb to 5 kb, and above 5 kb). Protein markers are further classified as (below ten kDa, ten kDa to 100 kDa, 100 kDa to 200 kDa, and above 200 kDa). The types of molecular weight markers considered in this study are unstained markers, stained markers, and specialty markers. The applications are categorized as nucleic acid applications and proteomics applications. The applications of nucleic acids are further classified as (PCR, sequencing, Northern blotting, Southern blotting, molecular cloning, and others). Proteomics applications are further classified as Western blotting, gel extraction, and others. Market size estimates and forecasts for these segments are provided in US$ Mn, along with the respective CAGRs for the period 2017-2025, using 2016 as the base year.

Market size estimates and forecasts for these segments are provided in US$ Mn, along with the respective CAGRs for the period 2017-2025, using 2016 as the base year.

This report also includes qualitative assessment factors such as market dynamics (drivers, restraints, and opportunities) to have a good understanding of the current and anticipated trends in the global molecular weight markers market. Competition assessment tools such as market attractiveness assessment and competitive landscape analysis by key players are also presented in the study. Furthermore, this report concludes with a profile of key market players currently enjoying prominent positions in the global molecular weight markers market. The key players profiled in this report are Agilent Technologies, Bio-Rad Laboratories, Inc., F. Hoffmann-La Roche Ltd., Merck KGaA, New England Biolabs, Promega Corp., Qiagen, Takara Bio, Inc., Thermo Fisher Scientific, Inc., VWR International, LLC, and other notable players.

Based on product, the global molecular weight markers market is categorized into

  • DNA Markers
    • Below 50 basis points
    • 50 BP to 100 BP
    • 100 bps to 1 kb
    • 1 kb to 5 kb
    • Above 5 kb
  • Protein Markers
    • Below ten kDa
    • Ten kDa to 100 kDa
    • 100 kDa to 200 kDa
    • Above 200 kDa
  • RNA Markers

The molecular weight market is driven by factors such as the rising need for personalized medicine for the treatment of chronic diseases and rare diseases with genetic disorders. Additionally, there has been enhanced funding for building the platform for optimal research to be carried out in proteomics and pharmacogenomics. Technological advancement in forensic homogenetic, where DNA molecular weight markers are employed in forensic single locus probe analysis.

In 2016, DNA markers held the largest market share, chiefly due to factors such as enhanced funding by government agencies and biopharmaceutical giants to boost the research and development activities related to genomics, where DNA markers are employed for genome mapping. Protein markers will be the fastest-growing market due to factors such as the rising prevalence of rare diseases and increasing funding in proteomics studies for new drug discovery and companion diagnostics. RNA markers are used to diagnose and predict the expression of microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and noncoding RNAs in cancers such as breast cancer, non-small cell lung cancer (NSCLC), and others. The major players in the molecular weight market are Agilent Technologies, Bio-Rad Laboratories, Inc., F. Hoffmann-La Roche Ltd., Merck KGaA, New England Biolabs, Promega Corp., Qiagen, and Takara Bio, Inc. Thermo Fisher Scientific, Inc.; VWR International, LLC.

Based on type, the global molecular weight markers market is categorized into

  • Unstained Markers
  • Prestained Markers
  • Specialty Markers

In 2016, prestained markers held the largest market share, chiefly due to factors such as their excellent performance in a variety of gel compositions and concentrations; additionally, it offers advantages such as the ability to monitor the progress of an electrophoretic run, exceptional resolution, no thaw cycle required, and no chemical reduction required before gel loading. Additionally, after the electrophoresis run, these prestained markers can be transferred from SDS-PAGE gels to solid-phase supports such as polyvinylidene difluoride (PVDF), nitrocellulose, nylon, etc. Unstained markers will be the fastest-growing segment throughout the forecast period. Its ability to accurately determine the molecular weight of the sample with uniform band intensities on SDS-PAGE gels stained with Coomassie Blue or zinc supports the growth of this segment. Few unstained markers are streptavidin-tagged, allowing vector immunodetection in western blot techniques. Specialty markers offer a lucrative market opportunity due to the increasing demand for PageRuler NIR Protein Ladder for near-IR fluorescent visualization and molecular weight estimation following electrophoresis. Benchmark histidine-tagged protein standard for use in fluorescence molecular weight detection of his-proteins and for its ease of resolution with ultraviolet light.

Based on application, the global molecular weight markers market is categorized into

  • Nucleic Acid Applications
    • PCR
    • Sequencing
    • Northern Blotting
    • Southern Blotting
    • Molecular Cloning
    • Others
  • Proteomics Applications
    • Western Blotting
    • Gel Extraction
    • Others

The molecular weight markers industry is witnessing tremendous growth, significantly due to factors such as public-private partnerships resulting in the expansion of the research and development segment of the pharmaceutical and biotechnology industries. Rare disease diagnosis and treatment have been an eye-catcher for the last decade, leading to the incumbent demand for genome mapping to determine the biomarkers and targeted drug delivery to suppress the genetic factors responsible for the etiology of rare diseases.

In 2016, nucleic acid applications dominated the market. Factors such as the increasing demand for blotting techniques for the detection and transfer of DNA fragments onto a carrier, allowing its use for gel electrophoresis, drive this segment. Moreover, blotting techniques find huge applications in gene discovery, DNA fingerprinting, diagnostics and forensics, and the identification of transferred genes in transgenic individuals. The proteomics applications segment is anticipated to register faster growth throughout the forecast period of 2017–2025, mainly attributed to the rising prevalence of chronic diseases and increased public health awareness resulting in early disease diagnosis and treatment. The proteomics research has a wide range of applications, including elucidating the additional components of microbe biochemical pathways and analyzing post-translational modification in drug-resistant bacteria.

For the purpose of this study, the global market for molecular weight markers is categorized into the following regional and country-specific markets:

  • North America
    • U.S.
    • Canada
  • Europe
    • U.K.
    • Germany
    • France
    • Rest of Europe
  • Asia Pacific
    • China
    • Japan
    • India
    • Rest of Asia Pacific
  • Latin America
    • Brazil
    • Mexico
    • rest of Latin America
  • Middle East and Africa
    • GCC
    • Rest of the Middle East and Africa

In the base year 2016, North America was observed to be the largest market for molecular weight markers. The dominance of North America is mainly attributed to the presence of large research laboratories specializing in biotechnology research and the existence of developed research and healthcare institutions. The market growth in Europe is mainly attributed to the increasing number of patients suffering from chronic and rare diseases. This factor boosts the demand for the determination of the biomarkers aberrantly present in chronic diseases such as diabetes, cancer, cardiovascular complications, etc., which could be expressed and targeted for treatment. Asia Pacific is estimated to be the fastest-growing regional segment throughout the forecast period of 2017–2025. Factors that are anticipated to propel the market growth are the presence of a large patient pool that can be enrolled in biopsy studies for the determination of disease etiology and to test the drug treatment regimen during clinical trials; a competitive market due to the presence of existing major players and evolving biopharmaceutical companies involved in the manufacturing of molecular weight markers in this region; and a supportive regulatory environment for molecular weight marker products. Moreover, factors such as developing health infrastructure and the establishment of research centers by major biopharmaceutical companies are going to fuel the rapid growth of the molecular weight marker market in Latin America, the Middle East, and Africa in the near future.

Frequently Asked Questions:

The market for Molecular Weight Markers is expected to reach US$ 1,267.3 Mn in 2025.

The Molecular Weight Markers market is expected to see significant CAGR growth over the coming years,at 12.63%.

The report is forecasted from 2017-2025.

The base year of this report is 2016.

Agilent Technologies,Bio-Rad Laboratories, Inc.,F.Hoffman La-Roche Ltd.,Merck KGaA,New England Biolabs are some of the major players in the global market.

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Published Date:  Oct 2017
Category:  Biotechnology
Report ID:   58750
Report Format:   PDF
Pages:   120
Rating:    4.8 (80)
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