N-Acetylcysteine Market by Product Type (Spray, Tablet, Tracheal Drip) by Application (Medicine, Nutritional Supplements, Others): Growth, Future Prospects, and Competitive Analysis, 2015 - 2027

Market Insights:

N-Acetylcysteine is a supplement form of amino acid named cysteine. It facilitates the bonding of amino acids glycine and glutamine for the creation of an essential antioxidant glutathione inside the human body. N-Acetylcysteine has applications as medicines and nutritional supplements. The global market is going to reach at USD 2,200 million in 2027 from USD 1,032.6 million in 2020, expanding at a CAGR of 21.3% during the period 2021 to 2027.

N-Acetylcysteine Market

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Increasing Incidence Rate of Paracetamol Overdose

The increasing demand for N-Acetylcysteine for treating acetaminophen poisoning and the increasing usage of N-Acetylcysteine across the healthcare industry is projected to bolster the market. Demand for acetaminophen is growing at a rapid pace, and so as the cases of paracetamol overdosing. Countries like the U.K., Australia, and the U.S. are facing a higher growth rate of paracetamol overdosing as compared to the growth rate of paracetamol itself. For instance, the number of paracetamol poisoning cases has increased by over 40% during the past decade in U.K. and Australia. The major reason behind increasing paracetamol poisoning is the availability of paracetamol over the counter around the world. N-Acetylcysteine is crucial in maintaining or restoring the depleted glutathione in the liver to improve the non-toxic metabolism of paracetamol.    

However, certain adverse effects are also associated with the intake of N-Acetylcysteine. First, when taken in IV formulations, N-Acetylcysteine causes rash, itchiness, and urticaria. In addition, nausea, vomiting, fever, etc., are some of the most commonly found side effects of N-Acetylcysteine when taken in the form of inhalation formulation. While, oral intake of N-Acetylcysteine shows side effects such as rash, nausea, vol=mitting, etc. Secondly, if taken immediately before or after alcohol consumption, N-Acetylcysteine causes serious liver damage.

Impact of COVID 19

COVID 19 had a significant impact on the global N-Acetylcysteine industry. As the hospitals focused on treating COVID 19 patients, the treatments for other ailments were deferred. It affected the sales of N-Acetylcysteine initially. The COVID-19 restrictions affected the production of N-Acetylcysteine at the beginning on account of disruption in logistics. However, when the restrictions were lifted, production improved. N-Acetylcysteine was given to COVID 19 patients with severe pulmonary ailments. It helped in the recovery of the global N-Acetylcysteine market to a certain extent. The global N-Acetylcysteine market is anticipated to better the pre-COVID 19 levels in the coming years.

N-Acetylcysteine Market


North America is the leading N-Acetylcysteine market globally.

North America reported the vast majority of N-Acetylcysteine consumption over the past few years and accounted for nearly 40% of total revenue generated in 2020. North America is reportedly having the largest share of the total number of paracetamol overdose incidences. Moreover, hypertoxicity caused owing to an overdose of paracetamol is also higher in North America and Europe as compared to the Asia Pacific. This, in turn, drives the demand for N-Acetylcysteine at a rapid pace in the region. The U.S. is witnessing consumption of an all-time high level of paracetamol consumption. More than sixty million United States citizens intake acetaminophen on a weekly basis, which ends up in ever-rising cases of overdosage. Paracetamol poisoning ultimately resulted in emergency visits in excess of 50 thousand, over 2,500 hospitalizations, and a mortality rate of over 500 per annum. 

Europe is the second leading geography for the consumption of N-Acetylcysteine as of 2020. The mortality rate of paracetamol overdosing has remained above 200 per annum in the U.K. alone. The Asia Pacific is also witnessing a strong growth rate on account of strong demand from China, India, Australia, Japan, South Korea, etc. Therefore, the demand for N-Acetylcysteine in the Asia Pacific is expected to grow at a rapid pace over the forecast period. Lack of awareness among end-users regarding side effects of N-Acetylcysteine, easy availability over the counter, and low cost of paracetamol is one of the major reasons behind overdose.       

Pulmonary ailments lead the global N-Acetylcysteine Market.

The nasal spray is leading the market for N-Acetylcysteine on account of growing chronic obstructive pulmonary disease and asthma. WHO has reported that over 65 million people worldwide suffer from chronic obstructive pulmonary disease, while asthma-related patients are reported to be over 335 million. This, in turn, drives the demand for nasal spray form of N-Acetylcysteine. Additionally, N-Acetylcysteine is one of the major drugs used in COVDI 19 patients suffering from severe pulmonary ailments. Similarly, oral and intravenous formulations are also used to treat different medical conditions.   

Medicine application to dominate the global demand for N-Acetylcysteine

The major applications of N-Acetylcysteine are medicine and nutritional supplements. However, treatment accounts for more than a 42.3% share of the overall revenue generated by the global N-Acetylcysteine industry. The presence of nearly 38 million HIV patients drives the demand for N-Acetylcysteine. Moreover, it is used for the treatment of fibrosis, pulmonary ailments, flu, psychiatric disorders, inflammations, acetaminophen poisoning, and other medical conditions.

Frequently asked questions about global N-Acetylcysteine industry

There was impact of COVID 19 on demand of N-Acetylcysteine, however, production was hampered which in turn resulted into supply shortage. Overall industry reported decline in market size by around 5 to 10%.

Cheng Yi Pharmaceutical Co Ltd, Donboo Amino Acid Co Ltd, Manus Aktteva Biopharma LLP, Moehs Group, etc. are some of the most prominent players in the world. Although North America dominate consumption, Asia Pacific is major production region for N-Acetylcysteine.

The report covers in detail information of paracetamol poisoning incidence rate, paracetamol consumption and mortality rate thereof.

Medicinal use is dominating the consumption of N-Acetylcysteine around the world. It accounted in excess to 40% share of the total revenue generated by the N-Acetylcysteine industry in 2020.

Driven by higher paracetamol poisoning rate, the North America is most dominating region for N-Acetylcysteine industry and its is closely followed by Europe.

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Published Date:  Aug 2021
Category:  Pharmaceuticals
Report ID:   60311
Report Format:   PDF
Pages:   120
Rating:    4.3 (58)
Delivery Time: 24 Hours to 48 Hours   
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