Home / Pharmaceuticals / Global Fabry Disease Therapeutic Market - Growth, Share, Opportunities & Competitive Analysis, 2016 - 2024

Global Fabry Disease Therapeutic Market - Growth, Share, Opportunities & Competitive Analysis, 2016 - 2024

Overview:

Fabry disease is a rare, X-linked inherited, disorder of lipid metabolism resulting from the deficient activity of the enzyme, alpha-galactosidase-A. This enzyme normally responsible for the breakdown of globotriaosylceramide, results in abnormal deposits of a particular fatty substance in walls of the blood vessel throughout the body. Characteristic features of Fabry disease include episodes of pain, cloudiness of the front part of the eye, clusters of small and dark red spots on the skin, hearing loss also involves life-threatening complications such as heart attack, kidney damage and stroke. Fabry disease can be divided into two types, type 1 classic phenotype and type 2 later-onset phenotype. According to National Organization for Rare Disorder (NORD) the incidence of type 1 classic phenotype is about 1 in 40,000 in males, but varies with demography and race, ranging from about 1 in 18,000 to 1 in 95,000. The incidence of type 2 later-onset in males varies by ethnicity, demography and race, but is at least 10 times more frequent than that of the type 1 classic phenotype from the same region, ethnic group or race.

There is no cure for Fabry disease, but medications are available treat the condition. Enzyme Replacement Therapy (ERT) is used for treatment. Currently only two ERT preparations such as Replagal and Fabrazyme are available in the market that are administered by intravenous infusion. In the USA, only Sanofi-Genzyme’s agalsidase beta (Fabrazyme) is FDA approved. Shire’s Agalsidase alfa (Replagal) is approved in Europe and many other countries but not in the United States. Fabrazyme and Replagal is administered after every two weeks for lifetime or until another appropriate medication becomes available. ERT is extremely expensive treatment. Other treatment may also involve medications to reduce symptoms such as pain medications, medications to treat stomach hyperactivity, blood thinners and medication to manage arrhythmias and other heart disorders.

Key drivers for the global fabry disease therapeutic market includes, extensive investigations and adoption of advance technology in research and development. Various therapeutic products, such as, SMP-536, PRX-102, AT-1001, GC-1119, SAR-402671, PRX-102 and other are in clinical trial studies. Fabry disease has been designated ICD-10-CM code by government and private insurance that can be used to indicate diagnosis for reimbursement purpose, which would further drive the market. Major barriers of growth for the global for Fabry disease market is rare incidence rate of the disorder (1:40,000).

Companies such as Genzyme-Sanofi and Shire are the major player in market as only these company have approved drugs in the market currently. Major players involved in development of new medications include Amicus therapeutics, Shire, Genzyme-Sanofi, Protalix, Sanofi-Aventis LLC, Novartis Pharmaceuticals, Pfizer, Bristol-Myers Squibb Company, GlaxoSmithKline plc, Amgen Inc., Teva pharmaceutical Industries Ltd., Merck & Co., AbbVie Inc., Takeda Pharmaceutical Co. Ltd., Green Cross Corp.

The Global Fabry Disease Therapeutic Market Is Segmented on the Following Bases:

  • Global Fabry disease drugs Market Revenue (USD Mn), By drug type, 2016-2024
    • Enzyme Replacement Therapy
    • Alternative therapies
  • Global Fabry Disease drugs Market Revenue (USD Mn), By Geography, 2016-2024
    • North America
      • US
      • Canada
    • Europe
      • UK
      • Germany
      • Rest of Europe
    • Asia-Pacific
      • Japan
      • China
      • Rest of APAC
    • Latin America
    • Middle East and Africa

Key Players Identified for Global Fabry Disease Therapeutic Market Include:

Amicus therapeutics, Shire, Genzyme-Sanofi, Protalix, Sanofi-Aventis LLC, Novartis Pharmaceuticals, Pfizer, Bristol-Myers Squibb Company, GlaxoSmithKline plc, Amgen Inc., Teva pharmaceutical Industries Ltd., Merc & Co., AbbVie Inc., Takeda Pharmaceutical Co. Ltd., Green Cross Corp.

This report offers:

  • An overview of the global markets for Fabry Disease Therapeutics
  • Market trends assessment for the period 2014-2024, with historical information for 2014 & 2015, and projections through 2024, with respective CAGRS during 2016-2024
  • Qualitative assessment tools such as market drivers, challenges and future prospects.
  • Market competition scrutiny tools such as market share analysis, fractal map assessment.
  • Focus on each level of market segmentation based on product approvals, launch, and current and anticipated market dynamics.
  • A general overview of the industry structure

Company profiles highlighting key information about the major players operating in the Fabry Disease Therapeutics Market

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