Fragment-based Drug Discovery Market

Market Insights

The global fragment-based drug discovery (FDD) market was worth US$ 503.4 million in 2017 and is expected to grow at a compound annual growth rate (CAGR) of 11.8% from 2018 to 2026. In the last two decades, fragment-based drug discovery has emerged as a significant substitute for high-throughput screening (HTS) for the identification of lead compounds for drug discovery. The introduction of novel techniques in the existing fragment-based drug discovery process has reduced the time and cost of production, which has led to a growing demand for fragment-based drug design.

In comparison to HTS, the fragment-based approach requires the screening of fewer compounds and offers more efficient and productive optimization of compounds. The growing uptake of FBDD by biopharmaceutical companies with the aim of cost-effectiveness and high productivity is projected to drive the fragment-based drug discovery market. Furthermore, the use of fragment-based drug discovery has increased the demand for highly specialized and efficient biophysical techniques capable of weak affinity interactions.

These include nuclear magnetic resonance (NMR) spectroscopy, x-ray crystallography, and capillary electrophoresis, among others. Technological advancements in these screening technologies will further drive the growth of the market. North America dominated the global fragment-based drug discovery market owing to high R&D by biopharmaceutical companies for time- and cost-efficient drug discovery techniques. Asia Pacific is projected to grow at the fastest rate during the forecast period due to the number of CROs operating in the region and the growing outsourcing of pharmaceutical manufacturing in the region.

Market Synopsis

Technological advancements to drive the fragment-based drug discovery market

In 2017, NMR spectroscopy and x-ray crystallography were the leading segments in the global fragment-based drug discovery market. NMR spectroscopy is highly productive and efficient due to recent modifications and is the most commonly used technique. Companies such as Abbott Laboratories, Novartis, and Roche are reported to be using NMR spectroscopy for fragment-based drug discovery. X-ray crystallography provides a detailed profile of fragment-binding, and identifying crystal structures has become a high-throughput process with the help of x-ray crystallography.

Moreover, x-ray crystallography is considered the gold standard in orthogonal fragment screening as it confirms the binding of the protein to the target. Other techniques that are extensively used for fragment-based drug discovery are capillary electrophoresis, surface plasmon resonance, mass spectroscopy, and differential scanning fluorimetry. These are expected to witness substantial growth during the forecast period, thereby driving the fragment-based drug discovery market.

Periods of History and Forecast

This research report presents the analysis of each segment from 2016 to 2026, considering 2017as the base year for the research. The compound annual growth rate (CAGR) for each of the respective segments was calculated for the forecast period from 2018 to 2026.

Report Scope by Segments

The Fragment-based Drug Discovery Market Report provides quantitative analysis as well as current market trends. The market is segmented based on service type, end-user, and geography.

The market is studied in order to understand the current dynamics and future trends in the global fragment-based drug discovery market. The study includes market size and forecasts for all considered segments presented in the report for the period from 2016 to 2026, along with respective compound annual growth rates (CAGRs) for the forecast period from 2018 to 2026, considering 2017 as the base year. The key players currently engaged in the fragment-based drug discovery market include Astex Pharmaceuticals, Charles River Laboratories International, Inc., Evotec AG, Kinetic Discovery Limited, and Alveus Pharmaceuticals Pvt. Ltd., among others.

Key questions are answered in this report.

• How will the global fragment-based drug discovery market perform during the forecast period from 2018 to 2026?
• What are the latest trends in the fragment-based drug discovery market and valuable opportunities for key players?
• Who are the leading players in the global fragment-based drug discovery market?
• Which is the leading and fastest-growing region in the global fragment-based drug discovery market?
• What are the drivers and restraints governing the global fragment-based drug discovery market?

Chapter 1. Preface
1.1. Report Description
1.1.1. Study Purpose
1.1.2. Target Audience
1.1.3. USP and Key Offerings
1.2. Research Scope
1.3. Research Methodology
1.3.1. Phase I – Secondary Research
1.3.2. Phase II – Primary Research
1.3.3. Phase III – Expert Panel Review
1.3.4. Assumptions
1.4. Market Segmentation

Chapter 2. Executive Summary
2.1. Global FDD Market Portraiture
2.2. Global FDD Market, by Service Type, 2017 (US$ Mn)
2.3. Global FDD Market, by End-User, 2017 (US$ Mn)
2.4. Global FDD Market, by Geography, 2017 (US$ Mn)

Chapter 3. Fragment-based Drug Discovery (FDD) Market Dynamics and Outlook
3.1. Market Overview
3.2. Drivers
3.3. Challenges
3.4. Opportunities
3.5. Attractive Investment Proposition, by Geography, 2017
3.6. Competitive Analysis: Global FDD Market, by Key Players, 2017

Chapter 4. Global Fragment-based Drug Discovery (FDD) Market, by Service Type, 2016-2026 (US$ Mn)
4.1. Overview
4.2. Fragment Screening Technique
4.2.1. NMR Spectroscopy
4.2.2. Differential Scanning Fluorimetry (DSF)
4.2.3. X-Ray Crystallography
4.2.4. Fluorescence Polarization (FP)
4.2.5. Isothermal Titration Calorimetry (ITC)
4.2.6. Surface Plasmon Resonance (SPR)
4.2.7. Mass Spectrometry (MS)
4.2.8. Capillary Electrophoresis (CE)
4.2.9. Others
4.3. Fragment Optimization Technique

Chapter 5. Global Fragment-based Drug Discovery (FDD) Market, by End-User, 2016 – 2026 (US$ Mn)
5.1. Overview
5.2. Biopharmaceutical Companies
5.3. Contract Research Organization
5.4. Academic and Research Institutions

Chapter 6. Global Fragment-based Drug Discovery (FDD) Market, by Geography, 2016 – 2026 (US$ Mn)
6.1. North America FDD Market Analysis, 2016 – 2026
6.1.1. North America FDD Market, by Service Type, 2016 – 2026 (US$ Mn)
6.1.2. North America FDD Market, by End-User, 2016 – 2026 (US$ Mn)
6.1.3. North America FDD Market, by Country, 2016 – 2026 (US$ Mn)
6.1.3.1. U.S.
6.1.3.2. Canada
6.2. Europe FDD Market Analysis, 2016 – 2026
6.2.1. Europe FDD Market, by Service Type, 2016 – 2026 (US$ Mn)
6.2.2. Europe FDD Market, by End-User, 2016 – 2026 (US$ Mn)
6.2.3. Europe FDD Market, by Country/Region, 2016 – 2026 (US$ Mn)
6.2.3.1. U.K.
6.2.3.2. Germany
6.2.3.3. Rest of Europe
6.3. Asia Pacific FDD Market Analysis, 2016 – 2026
6.3.1. Asia Pacific FDD Market, by Service Type, 2016 – 2026 (US$ Mn)
6.3.2. Asia Pacific FDD Market, by End-User, 2016 – 2026 (US$ Mn)
6.3.3. Asia Pacific FDD Market, by Country/Region, 2016 – 2026 (US$ Mn)
6.3.3.1. China
6.3.3.2. Japan
6.3.3.3. Rest of Asia Pacific
6.4. Latin America FDD Market Analysis, 2016 – 2026
6.4.1. Latin America FDD Market, by Service Type, 2016 – 2026 (US$ Mn)
6.4.2. Latin America FDD Market, by End-User, 2016 – 2026 (US$ Mn)
6.4.3. Latin America FDD Market, by Country/Region, 2016 – 2026 (US$ Mn)
6.4.3.1. Brazil
6.4.3.2. Mexico
6.4.3.3. Rest of Latin America
6.5. Middle East & Africa FDD Market, 2016 – 2026
6.5.1. Middle East & Africa FDD Market, by Service Type, 2016 – 2026 (US$ Mn)
6.5.2. Middle East & Africa FDD Market, by End-User, 2016 – 2026 (US$ Mn)
6.5.3. Middle East & Africa FDD Market, by Region, 2016 – 2026 (US$ Mn)
6.5.3.1. GCC
6.5.3.2. Rest of Middle East & Africa

Chapter 7. Company Profiles
7.1. Astex Pharmaceuticals
7.1.1. Business Description
7.1.2. Financial Information (Subject to Data Availability)
7.1.3. Product Portfolio
7.1.4. News Coverage
7.2. Alveus Pharmaceuticals Pvt. Ltd.
7.3. Beactica AB
7.4. Charles River Laboratories International, Inc.
7.5. Crown Bioscience, Inc.
7.6. Emerald BioStructures, Inc.
7.7. Evotec AG
7.8. Kinetic Discovery Limited
7.9. Proteros Fragments GmbH
7.10. Sprint Bioscience
7.11. Structure Based Design, Inc.
7.12. Sygnature Discovery

List of Figures

FIG 1. Fragment-based Drug Discovery (FDD) Market: Research Methodology
FIG 2. FDD Market Segmentation
FIG 3. Global FDD Market, by Service Type, 2017 (US$ Mn)
FIG 4. Global FDD Market, by End-User, 2017 (US$ Mn)
FIG 5. Global FDD Market, by Geography, 2017 (US$ Mn)
FIG 6. Attractive Investment Proposition, by Geography, 2017
FIG 7. Competitive Analysis: Global FDD Market, by Key Players, 2017
FIG 8. Global NMR Spectroscopy Market in Fragment-based Drug Discovery, 2016-2026 (US$ Mn)
FIG 9. Global Differential Scanning Fluorimetry (DSF) Market in Fragment-based Drug Discovery, 2016-2026(US$ Mn)
FIG 10. Global X-Ray Crystallography Market in Fragment-based Drug Discovery, 2016-2026(US$ Mn)
FIG 11. Global Fluorescence Polarization (FP) Market in Fragment-based Drug Discovery, 2016-2026(US$ Mn)
FIG 12. Global Isothermal Titration Calorimetry (ITC) Market in Fragment-based Drug Discovery, 2016-2026(US$ Mn)
FIG 13. Global Surface Plasmon Resonance (SPR) Market in Fragment-based Drug Discovery, 2016-2026(US$ Mn)
FIG 14. Global Mass Spectrometry Market in Fragment-based Drug Discovery, 2016-2026(US$ Mn)
FIG 15. Global Capillary Electrophoresis Market in Fragment-based Drug Discovery, 2016-2026(US$ Mn)
FIG 16. Global Other Services Market in Fragment-based Drug Discovery, 2016-2026(US$ Mn)
FIG 17. Global Fragment Optimization Technique Market in Fragment-based Drug Discovery, 2016-2026(US$ Mn)
FIG 18. Global Biopharmaceutical Companies End-User in FDD Market, 2016-2026(US$ Mn)
FIG 19. Global Contract Research Organization End-User in FDD Market, 2016-2026(US$ Mn)
FIG 20. Global Academic and Research Institutions End-User in FDD Market, 2016-2026(US$ Mn)
FIG 21. U.S. FDD Market, 2016-2026 (US$ Mn)
FIG 22. Canada FDD Market, 2016-2026 (US$ Mn)
FIG 23. U.K. FDD Market, 2016-2026 (US$ Mn)
FIG 24. Germany FDD Market, 2016-2026 (US$ Mn)
FIG 25. Rest of Europe FDD Market, 2016-2026 (US$ Mn)
FIG 26. China FDD Market, 2016-2026 (US$ Mn)
FIG 27. Japan FDD Market, 2016-2026 (US$ Mn)
FIG 28. Rest of Asia Pacific FDD Market, 2016-2026 (US$ Mn)
FIG 29. Brazil FDD Market, 2016-2026 (US$ Mn)
FIG 30. Mexico FDD Market, 2016-2026 (US$ Mn)
FIG 31. Rest of Latin America FDD Market, 2016-2026 (US$ Mn)
FIG 32. GCC FDD Market, 2016-2026 (US$ Mn)
FIG 33. Rest of Middle East & Africa FDD Market, 2016-2026 (US$ Mn)

List of Tables

TABLE 1 Global Fragment-based Drug Discovery (FDD) Market Portraiture
TABLE 2 Global FDD Market, by Service Type, 2016 – 2026 (US$ Mn)
TABLE 3 Global Fragment Screening Technique Market, by Type, 2016 – 2026 (US$ Mn)
TABLE 4 Global FDD Market, by End-User, 2016 – 2026 (US$ Mn)
TABLE 5 Global FDD Market, by Geography, 2016 – 2026 (US$ Mn)
TABLE 6 North America FDD Market, by Service Type, 2016 – 2026 (US$ Mn)
TABLE 7 North America FDD Market, by End-User, 2016 – 2026 (US$ Mn)
TABLE 8 North America FDD Market, by Country, 2016 – 2026 (US$ Mn)
TABLE 9 Europe FDD Market, by Service Type, 2016 – 2026 (US$ Mn)
TABLE 10 Europe FDD Market, by End-User, 2016 – 2026 (US$ Mn)
TABLE 11 Europe FDD Market, by Country/Region, 2016 – 2026 (US$ Mn)
TABLE 12 Asia Pacific FDD Market, by Service Type, 2016 – 2026 (US$ Mn)
TABLE 13 Asia Pacific FDD Market, by End-User, 2016 – 2026 (US$ Mn)
TABLE 14 Asia Pacific FDD Market, by Country/Region, 2016 – 2026 (US$ Mn)
TABLE 15 Latin America FDD Market, by Service Type, 2016 – 2026 (US$ Mn)
TABLE 16 Latin America FDD Market, by End-User, 2016 – 2026 (US$ Mn)
TABLE 17 Latin America FDD Market, by Country/Region, 2016 – 2026 (US$ Mn)
TABLE 18 Middle East & Africa FDD Market, by Service Type, 2016 – 2026 (US$ Mn)
TABLE 19 Middle East & Africa FDD Market, by End-User, 2016 – 2026 (US$ Mn)
TABLE 20 Middle East & Africa FDD Market, by Region, 2016 – 2026 (US$ Mn)
TABLE 21 Astex Pharmaceuticals: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 22 Alveus Pharmaceuticals Pvt. Ltd.: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 23 Beactica AB: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 24 Charles River Laboratories International, Inc.: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 25 Crown Bioscience, Inc.: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 26 Emerald BioStructures, Inc.: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 27 Evotec AG: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 28 Kinetic Discovery Limited: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 29 Proteros Fragments GmbH: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 30 Sprint Bioscience: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 31 Structure Based Design, Inc.: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 32 Sygnature Discovery: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)