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Oligonucleotide Synthesis Market By Product (Oligonucleotide-based drugs, Synthesized oligonucleotides, Reagents, Equipment) By Application (Therapeutic applications, Research applications, Diagnostic applications) – Growth, Share, Opportunities & Competitive Analysis, 2024 – 2032

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Published: | Report ID: 20092 | Report Format : PDF
REPORT ATTRIBUTE DETAILS
Historical Period 2019-2022
Base Year 2023
Forecast Period 2024-2032
Oligonucleotide Synthesis Market Size 2023 USD 7,452.19 million
Oligonucleotide Synthesis Market, CAGR 17.84%
Oligonucleotide Synthesis Market Size 2032 USD 32,652.66 million

Market Overview

The Global Oligonucleotide Synthesis Market is projected to grow from USD 7,452.19 million in 2023 to USD 32,652.66 million by 2032, at a compound annual growth rate of 17.84%.

The Global Oligonucleotide Synthesis Market is driven by increasing demand for personalized medicine, advancements in biotechnology, and rising investments in pharmaceutical research and development. Key trends include the growing application of oligonucleotides in therapeutic areas such as cancer, genetic disorders, and infectious diseases. Technological advancements in synthesis processes and the development of cost-effective and high-throughput synthesis techniques are also propelling market growth. Furthermore, collaborations and partnerships among key players to enhance product offerings and expand market reach are significantly shaping the market dynamics.

North America dominates the Global Oligonucleotide Synthesis Market, driven by robust pharmaceutical R&D activities, advanced healthcare infrastructure, and significant investments in biotechnology. Europe follows closely, benefiting from extensive academic research and government support for innovative therapies. The Asia-Pacific region is experiencing rapid market growth due to increasing healthcare expenditures, growing biotech industry, and rising prevalence of chronic diseases. Key players in the market include Thermo Fisher Scientific, Inc., Integrated DNA Technologies, Inc., BioAutomation Corporation, LGC Biosearch Technologies, and Merck KGaA, all of which are actively involved in strategic expansions, collaborations, and technological advancements to strengthen their market positions.

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Market Drivers

Increasing Demand for Oligonucleotide Therapeutics

Oligonucleotides, with their ability to precisely target specific genes, offer promising avenues for therapeutics across various diseases like cancer, neurodegenerative disorders, and infectious diseases. For example, in cancer treatment, oligonucleotides are being used to silence specific genes responsible for tumor growth, with over 30 oligonucleotide drugs currently in clinical trials. This surge in demand for oligonucleotide therapeutics is a primary driver propelling the oligonucleotide synthesis market forward. As researchers uncover the potential of oligonucleotide-based treatments, the market responds with increased production to meet the growing need for these innovative therapies.

Rising Adoption of Oligo-Based Products in Diagnostics

Beyond therapeutics, oligonucleotides find extensive use in diagnostic applications, aiding in the detection of gene mutations and identification of pathogens. In the field of infectious diseases, oligonucleotide-based tests have been crucial in identifying pathogens like the SARS-CoV-2 virus, with the global demand for COVID-19 testing driving a significant portion of the market. For example, the development of rapid, point-of-care diagnostic tests that utilize oligonucleotides has seen a surge, with the market for these tests expected to grow by 20% annually. These tests offer the advantage of quick and accurate detection, which is vital in managing outbreaks and ensuring timely treatment. Moreover, the precision of oligonucleotide-based diagnostics is leading to their increased adoption in personalized medicine. By identifying specific genetic markers, these diagnostics can guide tailored treatment plans, improving patient outcomes and contributing to the growth of the oligonucleotide synthesis market. As healthcare continues to evolve towards more personalized approaches, the demand for oligonucleotide-based diagnostics is anticipated to rise even further.

Technological Advancements Enhance Accessibility

Continual technological advancements are revolutionizing oligonucleotide synthesis, making it faster, cheaper, and more accessible. For instance, the time required for synthesizing a standard 20-mer oligonucleotide has been reduced from days to just a few hours, and the cost has decreased by approximately 50% over the past decade. These advancements not only streamline the synthesis process but also contribute to the affordability and availability of oligonucleotide-based therapies and diagnostics. As synthesis techniques evolve, the cost of raw materials has dropped significantly, with some estimates suggesting a reduction from $4 per base to under $0.05 per base. Consequently, oligonucleotide-based products become increasingly feasible for widespread adoption, driving market growth and expanding the reach of oligonucleotide-based solutions.

Growing Government Support Spurs Market Growth

Governments worldwide are increasingly recognizing the potential of oligonucleotide-based therapies and diagnostics, leading to heightened support for their development. This governmental backing plays a pivotal role in driving the growth of the oligonucleotide synthesis market by fostering research and innovation in the field. As government initiatives align with market demands, the oligonucleotide synthesis market continues to thrive, fueled by collaborative efforts aimed at advancing oligonucleotide-based solutions to address unmet medical needs.

Market Trends

Shift towards Therapeutic Applications and Revolutionizing Treatments

The therapeutic segment is poised to dominate the oligonucleotide synthesis market, driven by the growing approval of oligonucleotide-based drugs such as antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs). For instance, the FDA has approved several ASOs like Nusinersen for spinal muscular atrophy and Eteplirsen for Duchenne muscular dystrophy. These approvals reflect a broader trend, with the number of oligonucleotide drugs in clinical trials increasing from just a handful in the early 2000s to over 120 by 2021. This trend underscores the transformative potential of oligonucleotides in revolutionizing treatments, offering targeted solutions tailored to specific genetic factors. The increasing acceptance of oligonucleotide therapeutics signifies a paradigm shift towards precision medicine, where therapies are customized to individual patients. For example, the success rate of oligonucleotide therapeutics in clinical trials has improved, with a jump from an estimated 5% in the early 2010s to around 20% in recent years, ultimately enhancing treatment efficacy and patient outcomes.

Technological Advancements Enhancing Synthesis Efficiency innovations in automation and microfluidic technologies are significantly reshaping oligonucleotide synthesis. For instance, automation has led to a reduction in synthesis time by up to 60%, while also decreasing human error rates from approximately 5% to less than 0.5%. Microfluidic platforms, on the other hand, have enabled a more precise control over reaction conditions, which has resulted in yield improvements from 70% to over 90% and purity levels that exceed 99%. This technological evolution not only accelerates the synthesis of oligonucleotide therapeutics and diagnostics but also lowers manufacturing costs. For example, the cost of synthesizing a single oligonucleotide has decreased from $300 to $50, thereby facilitating broader adoption and affordability. As these advancements continue to refine synthesis methodologies, the potential for oligonucleotide-based therapies and diagnostics to address unmet medical needs grows exponentially.

Market Challenges Analysis

Addressing Delivery Hurdles for Oligonucleotide Drugs

Delivering oligonucleotide drugs to specific targets within the body remains a formidable challenge due to their limited ability to penetrate cell membranes and reach their intended sites of action. Overcoming these delivery hurdles necessitates innovative strategies such as nanoparticle-based delivery systems, lipid-based carriers, and cell-penetrating peptides. Developing effective delivery mechanisms is crucial for maximizing the therapeutic potential of oligonucleotide drugs and ensuring their clinical success. Researchers and pharmaceutical companies continue to explore novel delivery approaches to enhance the bioavailability and target specificity of oligonucleotide therapeutics, addressing a critical barrier to their widespread adoption.

Mitigating High Manufacturing Costs

The complex and precise nature of oligonucleotide synthesis contributes to high manufacturing costs, posing a significant barrier to the accessibility of oligonucleotide-based therapies for patients. Reducing these costs is imperative for enhancing affordability and expanding patient access to these innovative treatments. Efforts to mitigate high manufacturing costs include process optimization, automation of synthesis workflows, and the development of more cost-effective synthesis chemistries. By streamlining production processes and implementing cost-saving measures, pharmaceutical companies aim to make oligonucleotide-based therapies more economically viable without compromising quality or efficacy. Overcoming the challenge of high manufacturing costs is essential for realizing the full therapeutic potential of oligonucleotide drugs and advancing patient care.

Market Segmentation Analysis:

By Product:

The Global Oligonucleotide Synthesis Market encompasses a diverse range of products catering to various applications within the biotechnology and pharmaceutical sectors. The market is segmented into oligonucleotide-based drugs, synthesized oligonucleotides, reagents, and equipment. Oligonucleotide-based drugs represent a significant segment driven by the growing approval and adoption of therapeutic oligonucleotides for treating a multitude of diseases. Synthesized oligonucleotides, including custom-designed sequences, play a pivotal role in both research and diagnostic applications. Reagents such as enzymes, primers, and buffers are essential components for oligonucleotide synthesis, supporting the efficient production of high-quality oligonucleotides. Equipment utilized in synthesis processes, including synthesizers, purification systems, and analyzers, form another integral segment of the market, facilitating streamlined and scalable production workflows. The segmentation of the market by product highlights the diverse array of offerings catering to the evolving needs of researchers, clinicians, and biopharmaceutical companies engaged in oligonucleotide-based research, development, and commercialization efforts.

By Application:

The Global Oligonucleotide Synthesis Market is further segmented based on application into therapeutic, research, and diagnostic applications. Therapeutic applications represent a prominent segment, driven by the increasing approval and adoption of oligonucleotide-based drugs for targeted therapies in areas such as oncology, genetic disorders, and infectious diseases. Research applications encompass a broad spectrum of activities, including gene expression analysis, gene editing, and functional genomics, where synthesized oligonucleotides serve as indispensable tools for molecular biology research. Diagnostic applications, leveraging the specificity and sensitivity of oligonucleotides, play a crucial role in disease detection, genotyping, and molecular diagnostics, contributing to the advancement of precision medicine. The segmentation by application underscores the multifaceted utility of oligonucleotides across diverse scientific disciplines and clinical settings, driving innovation and advancements in biomedicine.

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Segments:

Based on Product

  • Oligonucleotide-based drugs
  • Synthesized oligonucleotides
  • Reagents
  • Equipment

Based on Application

  • Therapeutic applications
  • Research applications
  • Diagnostic applications

Based on End-user

  • Hospitals
  • Pharmaceutical & biotechnology companies
  • CROS and CMOS
  • Diagnostic laboratories
  • Others

Based on the Geography:

  • North America
  • Asia-Pacific
  • South America
  • Europe
  • Middle East and Africa

Regional Analysis

North America

North America, comprising the United States and Canada, holds a dominant market share of approximately 38%. This region is a global leader in biotechnology research, with a strong emphasis on genomics, molecular diagnostics, and therapeutic applications of oligonucleotides. The presence of prominent pharmaceutical and biotechnology companies, along with well-established research institutions, has fueled the demand for oligonucleotide synthesis in North America.

Europe

Europe, including countries like Germany, the United Kingdom, and France, accounts for around 28% of the global market share. This region has a thriving biotechnology sector, with significant investments in research and development activities. The growing adoption of oligonucleotide-based diagnostics and therapeutics, coupled with favorable government initiatives and funding, has driven the market’s growth in Europe.

Key Player Analysis

  1. Thermo Fisher Scientific, Inc.
  2. Danaher Corporation
  3. Eurofins Scientific
  4. Kaneka Corporation
  5. Merck KGaA
  6. Alnylam Pharmaceuticals, Inc.
  7. Sarepta Therapeutics, Inc.
  8. Biogen Limited
  9. Cinven
  10. Ionis Pharmaceuticals, Inc.

Competitive Analysis

The Global Oligonucleotide Synthesis Market is characterized by the presence of several key players who drive innovation and market growth through extensive research and development efforts. Thermo Fisher Scientific, Inc. leads the market with its comprehensive portfolio of oligonucleotide synthesis products and services, bolstered by robust global distribution networks. Danaher Corporation, through its subsidiaries like Integrated DNA Technologies, offers advanced synthesis technologies and high-quality oligonucleotides, enhancing its competitive edge. Eurofins Scientific provides specialized oligonucleotide synthesis services, leveraging its expertise in genomic services. Merck KGaA and Kaneka Corporation are also significant players, known for their technological advancements and diverse product offerings. Companies like Alnylam Pharmaceuticals, Ionis Pharmaceuticals, and Sarepta Therapeutics focus on therapeutic applications, driving the market with their pipeline of innovative oligonucleotide-based drugs. Biogen Limited and Cinven contribute through strategic investments and partnerships, fostering market expansion. This competitive landscape is marked by continuous advancements and strategic collaborations aimed at addressing the growing demand for oligonucleotide-based solutions.

Recent Developments

  • In November 2023, LCG Biosearch Technologies, a business unit of LGC Limited, acquired PolyDesign to enhance its oligonucleotide synthesis capabilities using PolyDesign’s frit technology.
  • In October 2023, Integrated DNA Technologies (IDT), a subsidiary of Danaher Corporation, opened its therapeutic oligonucleotide manufacturing facility in Coralville, Iowa. This facility will produce reagents for cGMP cell & gene therapy, including single-guide RNAs and HDR donor oligos.
  • In July 2022, WuXi STA, a subsidiary of WuXi AppTec, launched a new large-scale oligonucleotide and peptide manufacturing facility at its Changzhou campus. This new launch enhances its capacity and capability to meet the fast-growing customer needs for oligonucleotide and peptide therapeutics development and manufacturing worldwide.
  • In  April 2022, Bachem entered a strategic collaboration with Eli Lilly & Company to develop and manufacture active pharmaceutical ingredients based on oligonucleotides, a rising new class of complex molecules. Under the agreement, Bachem provides the appropriate engineering infrastructure and expertise to implement Lilly’s novel oligonucleotide manufacturing technology.

Market Concentration & Characteristics

The Global Oligonucleotide Synthesis Market exhibits moderate to high market concentration, with several dominant players holding significant market shares. Leading companies such as Thermo Fisher Scientific, Inc., Danaher Corporation, and Merck KGaA leverage their extensive research capabilities, advanced technologies, and comprehensive product portfolios to maintain competitive advantages. The market is characterized by continuous innovation, with a strong focus on the development of cost-effective and high-throughput synthesis techniques. Additionally, strategic collaborations and partnerships are prevalent, enabling companies to expand their technological expertise and market reach. Despite the concentration of key players, the market also provides opportunities for smaller and emerging companies to thrive, driven by the increasing demand for oligonucleotide-based therapeutics, diagnostics, and research applications. The dynamic nature of the market, characterized by rapid technological advancements and a growing emphasis on personalized medicine, underscores the competitive and evolving landscape of the oligonucleotide synthesis industry.

Report Coverage

The research report offers an in-depth analysis based on Product, Application, End-user and Geography. It details leading market players, providing an overview of their business, product offerings, investments, revenue streams, and key applications. Additionally, the report includes insights into the competitive environment, SWOT analysis, current market trends, as well as the primary drivers and constraints. Furthermore, it discusses various factors that have driven market expansion in recent years. The report also explores market dynamics, regulatory scenarios, and technological advancements that are shaping the industry. It assesses the impact of external factors and global economic changes on market growth. Lastly, it provides strategic recommendations for new entrants and established companies to navigate the complexities of the market.

Future Outlook

  1. The Global Oligonucleotide Synthesis Market is expected to see significant growth due to rising demand for personalized medicine.
  2. Advancements in synthesis technologies will make oligonucleotide production faster and more cost-effective.
  3. Increased regulatory approvals for oligonucleotide-based drugs will drive market expansion.
  4. Growing applications in gene editing and CRISPR therapies will create new opportunities.
  5. Enhanced delivery mechanisms will improve the efficacy of oligonucleotide therapeutics.
  6. Investments in automation and high-throughput synthesis platforms will streamline production processes.
  7. The market will benefit from expanding diagnostic applications, particularly in precision medicine.
  8. Collaboration between biotech firms and research institutions will spur innovation.
  9. Government support and funding will accelerate research and development efforts.
  10. Ethical considerations and regulatory frameworks will evolve to address the complexities of gene modification technologies.

CHAPTER NO. 1 : INTRODUCTION 20

1.1.1. Report Description 20

Purpose of the Report 20

USP & Key Offerings 20

1.1.2. Key Benefits for Stakeholders 20

1.1.3. Target Audience 21

1.1.4. Report Scope 21

1.1.5. Regional Scope 22

CHAPTER NO. 2 : EXECUTIVE SUMMARY 23

2.1. Oligonucleotide Synthesis Market Snapshot 23

2.1.1. Global Oligonucleotide Synthesis Market, 2018 – 2032 (USD Million) 24

CHAPTER NO. 3 : GEOPOLITICAL CRISIS IMPACT ANALYSIS 25

3.1. Russia-Ukraine and Israel-Palestine War Impacts 25

CHAPTER NO. 4 : OLIGONUCLEOTIDE SYNTHESIS MARKET – INDUSTRY ANALYSIS 26

4.1. Introduction 26

4.2. Market Drivers 27

4.2.1. Driving Factor 1 Analysis 27

4.2.2. Driving Factor 2 Analysis 28

4.3. Market Restraints 29

4.3.1. Restraining Factor Analysis 29

4.4. Market Opportunities 30

4.4.1. Market Opportunity Analysis 30

4.5. Porter’s Five Forces Analysis 31

CHAPTER NO. 5 : ANALYSIS COMPETITIVE LANDSCAPE 32

5.1. Company Market Share Analysis – 2023 32

5.1.1. Global Oligonucleotide Synthesis Market: Company Market Share, by Volume, 2023 32

5.1.2. Global Oligonucleotide Synthesis Market: Company Market Share, by Revenue, 2023 33

5.1.3. Global Oligonucleotide Synthesis Market: Top 6 Company Market Share, by Revenue, 2023 33

5.1.4. Global Oligonucleotide Synthesis Market: Top 3 Company Market Share, by Revenue, 2023 34

5.2. Global Oligonucleotide Synthesis Market Company Revenue Market Share, 2023 35

5.3. Company Assessment Metrics, 2023 36

5.3.1. Stars 36

5.3.2. Emerging Leaders 36

5.3.3. Pervasive Players 36

5.3.4. Participants 36

5.4. Start-ups /SMEs Assessment Metrics, 2023 36

5.4.1. Progressive Companies 36

5.4.2. Responsive Companies 36

5.4.3. Dynamic Companies 36

5.4.4. Starting Blocks 36

5.5. Strategic Developments 37

5.5.1. Acquisitions & Mergers 37

New Product Launch 37

Global Expansion 37

5.6. Key Players Product Matrix 38

CHAPTER NO. 6 : PESTEL & ADJACENT MARKET ANALYSIS 39

6.1. PESTEL 39

6.1.1. Political Factors 39

6.1.2. Economic Factors 39

6.1.3. Social Factors 39

6.1.4. Technological Factors 39

6.1.5. Environmental Factors 39

6.1.6. Legal Factors 39

6.2. Adjacent Market Analysis 39

CHAPTER NO. 7 : OLIGONUCLEOTIDE SYNTHESIS MARKET – BY PRODUCT SEGMENT ANALYSIS 40

7.1. Oligonucleotide Synthesis Market Overview, by Product Segment 40

7.1.1. Oligonucleotide Synthesis Market Revenue Share, By Product, 2023 & 2032 41

7.1.2. Oligonucleotide Synthesis Market Attractiveness Analysis, By Product 42

7.1.3. Incremental Revenue Growth Opportunity, by Product, 2024 – 2032 42

7.1.4. Oligonucleotide Synthesis Market Revenue, By Product, 2018, 2023, 2027 & 2032 43

7.2. Oligonucleotide-based drugs 44

7.3. Synthesized oligonucleotides 45

7.4. Reagents 46

7.5. Equipment 47

CHAPTER NO. 8 : OLIGONUCLEOTIDE SYNTHESIS MARKET – BY APPLICATION SEGMENT ANALYSIS 48

8.1. Oligonucleotide Synthesis Market Overview, by Application Segment 48

8.1.1. Oligonucleotide Synthesis Market Revenue Share, By Application, 2023 & 2032 49

8.1.2. Oligonucleotide Synthesis Market Attractiveness Analysis, By Application 50

8.1.3. Incremental Revenue Growth Opportunity, by Application, 2024 – 2032 50

8.1.4. Oligonucleotide Synthesis Market Revenue, By Application, 2018, 2023, 2027 & 2032 51

8.2. Therapeutic applications 52

8.3. Research applications 53

8.4. Diagnostic applications 54

CHAPTER NO. 9 : OLIGONUCLEOTIDE SYNTHESIS MARKET – BY END-USER SEGMENT ANALYSIS 55

9.1. Oligonucleotide Synthesis Market Overview, by End-user Segment 55

9.1.1. Oligonucleotide Synthesis Market Revenue Share, By End-user, 2023 & 2032 56

9.1.2. Oligonucleotide Synthesis Market Attractiveness Analysis, By End-user 57

9.1.3. Incremental Revenue Growth Opportunity, by End-user, 2024 – 2032 57

9.1.4. Oligonucleotide Synthesis Market Revenue, By End-user, 2018, 2023, 2027 & 2032 58

9.2. Hospitals 59

9.3. Pharmaceutical & biotechnology companies 60

9.4. CROS and CMOS 61

9.5. Diagnostic laboratories 62

9.6. Others 63

CHAPTER NO. 10 : OLIGONUCLEOTIDE SYNTHESIS MARKET – GLOBAL ANALYSIS 64

10.1. Product 64

10.1.1. Global Oligonucleotide Synthesis Market Revenue, By Product, 2018 – 2023 (USD Million) 64

10.2. Global Oligonucleotide Synthesis Market Revenue, By Product, 2024 – 2032 (USD Million) 64

10.3. Application 65

10.3.1. Global Oligonucleotide Synthesis Market Revenue, By Application, 2018 – 2023 (USD Million) 65

10.3.2. Global Oligonucleotide Synthesis Market Revenue, By Application, 2024 – 2032 (USD Million) 65

10.4. End-user 66

10.4.1. Global Oligonucleotide Synthesis Market Revenue, By End-user, 2018 – 2023 (USD Million) 66

10.4.2. Global Oligonucleotide Synthesis Market Revenue, By End-user, 2024 – 2032 (USD Million) 66

CHAPTER NO. 11 : OLIGONUCLEOTIDE SYNTHESIS MARKET – NORTH AMERICA 67

11.1. North America 67

11.1.1. Key Highlights 67

11.1.2. North America Oligonucleotide Synthesis Market Revenue, By Country, 2018 – 2023 (USD Million) 68

11.1.3. North America Oligonucleotide Synthesis Market Revenue, By Product, 2018 – 2023 (USD Million) 69

11.1.4. North America Oligonucleotide Synthesis Market Revenue, By Application, 2018 – 2023 (USD Million) 70

11.1.5. North America Oligonucleotide Synthesis Market Revenue, By End-user, 2018 – 2023 (USD Million) 71

11.2. U.S. 72

11.3. Canada 72

11.4. Mexico 72

CHAPTER NO. 12 : OLIGONUCLEOTIDE SYNTHESIS MARKET – EUROPE 73

12.1. Europe 73

12.1.1. Key Highlights 73

12.1.2. Europe Oligonucleotide Synthesis Market Revenue, By Country, 2018 – 2023 (USD Million) 74

12.1.3. Europe Oligonucleotide Synthesis Market Revenue, By Product, 2018 – 2023 (USD Million) 75

12.1.4. Europe Oligonucleotide Synthesis Market Revenue, By Application, 2018 – 2023 (USD Million) 76

12.1.5. Europe Oligonucleotide Synthesis Market Revenue, By End-user, 2018 – 2023 (USD Million) 77

12.2. UK 78

12.3. France 78

12.4. Germany 78

12.5. Italy 78

12.6. Spain 78

12.7. Russia 78

12.8. Belgium 78

12.9. Netherland 78

12.10. Austria 78

12.11. Sweden 78

12.12. Poland 78

12.13. Denmark 78

12.14. Switzerland 78

12.15. Rest of Europe 78

CHAPTER NO. 13 : OLIGONUCLEOTIDE SYNTHESIS MARKET – ASIA PACIFIC 79

13.1. Asia Pacific 79

13.1.1. Key Highlights 79

13.1.2. Asia Pacific Oligonucleotide Synthesis Market Revenue, By Country, 2018 – 2023 (USD Million) 80

13.1.3. Asia Pacific Oligonucleotide Synthesis Market Revenue, By Product, 2018 – 2023 (USD Million) 81

13.1.4. Asia Pacific Oligonucleotide Synthesis Market Revenue, By Application, 2018 – 2023 (USD Million) 82

13.1.5. Asia Pacific Oligonucleotide Synthesis Market Revenue, By End-user, 2018 – 2023 (USD Million) 83

13.2. China 84

13.3. Japan 84

13.4. South Korea 84

13.5. India 84

13.6. Australia 84

13.7. Thailand 84

13.8. Indonesia 84

13.9. Vietnam 84

13.10. Malaysia 84

13.11. Philippines 84

13.12. Taiwan 84

13.13. Rest of Asia Pacific 84

CHAPTER NO. 14 : OLIGONUCLEOTIDE SYNTHESIS MARKET – LATIN AMERICA 85

14.1. Latin America 85

14.1.1. Key Highlights 85

14.1.2. Latin America Oligonucleotide Synthesis Market Revenue, By Country, 2018 – 2023 (USD Million) 86

14.1.3. Latin America Oligonucleotide Synthesis Market Revenue, By Product, 2018 – 2023 (USD Million) 87

14.1.4. Latin America Oligonucleotide Synthesis Market Revenue, By Application, 2018 – 2023 (USD Million) 88

14.1.5. Latin America Oligonucleotide Synthesis Market Revenue, By End-user, 2018 – 2023 (USD Million) 89

14.2. Brazil 90

14.3. Argentina 90

14.4. Peru 90

14.5. Chile 90

14.6. Colombia 90

14.7. Rest of Latin America 90

CHAPTER NO. 15 : OLIGONUCLEOTIDE SYNTHESIS MARKET – MIDDLE EAST 91

15.1. Middle East 91

15.1.1. Key Highlights 91

15.1.2. Middle East Oligonucleotide Synthesis Market Revenue, By Country, 2018 – 2023 (USD Million) 92

15.1.3. Middle East Oligonucleotide Synthesis Market Revenue, By Product, 2018 – 2023 (USD Million) 93

15.1.4. Middle East Oligonucleotide Synthesis Market Revenue, By Application, 2018 – 2023 (USD Million) 94

15.1.5. Middle East Oligonucleotide Synthesis Market Revenue, By End-user, 2018 – 2023 (USD Million) 95

15.2. UAE 96

15.3. KSA 96

15.4. Israel 96

15.5. Turkey 96

15.6. Iran 96

15.7. Rest of Middle East 96

CHAPTER NO. 16 : OLIGONUCLEOTIDE SYNTHESIS MARKET – AFRICA 97

16.1. Africa 97

16.1.1. Key Highlights 97

16.1.2. Africa Oligonucleotide Synthesis Market Revenue, By Country, 2018 – 2023 (USD Million) 98

16.1.3. Africa Oligonucleotide Synthesis Market Revenue, By Product, 2018 – 2023 (USD Million) 99

16.1.4. Africa Oligonucleotide Synthesis Market Revenue, By Application, 2018 – 2023 (USD Million) 100

16.1.5. Africa Oligonucleotide Synthesis Market Revenue, By End-user, 2018 – 2023 (USD Million) 101

16.2. Egypt 102

16.3. Nigeria 102

16.4. Algeria 102

16.5. Morocco 102

16.6. Rest of Africa 102

CHAPTER NO. 17 : COMPANY PROFILES 103

17.1. Thermo Fisher Scientific, Inc. 103

17.1.1. Company Overview 103

17.1.2. Product Portfolio 103

17.1.3. Swot Analysis 103

17.1.4. Business Strategy 104

17.1.5. Financial Overview 104

17.2. Danaher Corporation 105

17.3. Eurofins Scientific 105

17.4. Kaneka Corporation 105

17.5. Merck Kgaa 105

17.6. Alnylam Pharmaceuticals, Inc. 105

17.7. Sarepta Therapeutics, Inc., 105

17.8. Biogen Limited 105

17.9. Cinven 105

17.10. Ionis Pharmaceuticals, Inc. 105

CHAPTER NO. 18 : RESEARCH METHODOLOGY 106

18.1. Research Methodology 106

18.1.1. Phase I – Secondary Research 107

18.1.2. Phase II – Data Modeling 107

Company Share Analysis Model 108

Revenue Based Modeling 108

18.1.3. Phase III – Primary Research 109

18.1.4. Research Limitations 110

Assumptions 110

List of Figures

FIG NO. 1. Global Oligonucleotide Synthesis Market Revenue, 2018 – 2032 (USD Million) 24

FIG NO. 2. Porter’s Five Forces Analysis for Global Oligonucleotide Synthesis Market 31

FIG NO. 3. Company Share Analysis, 2023 32

FIG NO. 4. Company Share Analysis, 2023 33

FIG NO. 5. Company Share Analysis, 2023 33

FIG NO. 6. Company Share Analysis, 2023 34

FIG NO. 7. Oligonucleotide Synthesis Market – Company Revenue Market Share, 2023 35

FIG NO. 8. Oligonucleotide Synthesis Market Revenue Share, By Product, 2023 & 2032 41

FIG NO. 9. Market Attractiveness Analysis, By Product 42

FIG NO. 10. Incremental Revenue Growth Opportunity by Product, 2024 – 2032 42

FIG NO. 11. Oligonucleotide Synthesis Market Revenue, By Product, 2018, 2023, 2027 & 2032 43

FIG NO. 12. Global Oligonucleotide Synthesis Market for Oligonucleotide-based drugs, Revenue (USD Million) 2018 – 2032 44

FIG NO. 13. Global Oligonucleotide Synthesis Market for Synthesized oligonucleotides, Revenue (USD Million) 2018 – 2032 45

FIG NO. 14. Global Oligonucleotide Synthesis Market for Reagents, Revenue (USD Million) 2018 – 2032 46

FIG NO. 15. Global Oligonucleotide Synthesis Market for Equipment, Revenue (USD Million) 2018 – 2032 47

FIG NO. 16. Oligonucleotide Synthesis Market Revenue Share, By Application, 2023 & 2032 49

FIG NO. 17. Market Attractiveness Analysis, By Application 50

FIG NO. 18. Incremental Revenue Growth Opportunity by Application, 2024 – 2032 50

FIG NO. 19. Oligonucleotide Synthesis Market Revenue, By Application, 2018, 2023, 2027 & 2032 51

FIG NO. 20. Global Oligonucleotide Synthesis Market for Therapeutic applications, Revenue (USD Million) 2018 – 2032 52

FIG NO. 21. Global Oligonucleotide Synthesis Market for Research applications, Revenue (USD Million) 2018 – 2032 53

FIG NO. 22. Global Oligonucleotide Synthesis Market for Diagnostic applications, Revenue (USD Million) 2018 – 2032 54

FIG NO. 23. Oligonucleotide Synthesis Market Revenue Share, By End-user, 2023 & 2032 56

FIG NO. 24. Market Attractiveness Analysis, By End-user 57

FIG NO. 25. Incremental Revenue Growth Opportunity by End-user, 2024 – 2032 57

FIG NO. 26. Oligonucleotide Synthesis Market Revenue, By End-user, 2018, 2023, 2027 & 2032 58

FIG NO. 27. Global Oligonucleotide Synthesis Market for Hospitals, Revenue (USD Million) 2018 – 2032 59

FIG NO. 28. Global Oligonucleotide Synthesis Market for Pharmaceutical & biotechnology companies, Revenue (USD Million) 2018 – 2032 60

FIG NO. 29. Global Oligonucleotide Synthesis Market for CROS and CMOS, Revenue (USD Million) 2018 – 2032 61

FIG NO. 30. Global Oligonucleotide Synthesis Market for Diagnostic laboratories, Revenue (USD Million) 2018 – 2032 62

FIG NO. 31. Global Oligonucleotide Synthesis Market for Others, Revenue (USD Million) 2018 – 2032 63

FIG NO. 32. North America Oligonucleotide Synthesis Market Revenue, 2018 – 2032 (USD Million) 67

FIG NO. 33. Europe Oligonucleotide Synthesis Market Revenue, 2018 – 2032 (USD Million) 73

FIG NO. 34. Asia Pacific Oligonucleotide Synthesis Market Revenue, 2018 – 2032 (USD Million) 79

FIG NO. 35. Latin America Oligonucleotide Synthesis Market Revenue, 2018 – 2032 (USD Million) 85

FIG NO. 36. Middle East Oligonucleotide Synthesis Market Revenue, 2018 – 2032 (USD Million) 91

FIG NO. 37. Africa Oligonucleotide Synthesis Market Revenue, 2018 – 2032 (USD Million) 97

FIG NO. 38. Research Methodology – Detailed View 106

FIG NO. 39. Research Methodology 107

List of Tables

TABLE NO. 1. : Global Oligonucleotide Synthesis Market: Snapshot 23

TABLE NO. 2. : Drivers for the Oligonucleotide Synthesis Market: Impact Analysis 27

TABLE NO. 3. : Restraints for the Oligonucleotide Synthesis Market: Impact Analysis 29

TABLE NO. 4. : Global Oligonucleotide Synthesis Market Revenue, By Product, 2018 – 2023 (USD Million) 64

TABLE NO. 5. : Global Oligonucleotide Synthesis Market Revenue, By Product, 2024 – 2032 (USD Million) 64

TABLE NO. 6. : Global Oligonucleotide Synthesis Market Revenue, By Application, 2018 – 2023 (USD Million) 65

TABLE NO. 7. : Global Oligonucleotide Synthesis Market Revenue, By Application, 2024 – 2032 (USD Million) 65

TABLE NO. 8. : Global Oligonucleotide Synthesis Market Revenue, By End-user, 2018 – 2023 (USD Million) 66

TABLE NO. 9. : Global Oligonucleotide Synthesis Market Revenue, By End-user, 2024 – 2032 (USD Million) 66

TABLE NO. 10. : North America Oligonucleotide Synthesis Market Revenue, By Country, 2018 – 2023 (USD Million) 68

TABLE NO. 11. : North America Oligonucleotide Synthesis Market Revenue, By Country, 2024 – 2032 (USD Million) 68

TABLE NO. 12. : North America Oligonucleotide Synthesis Market Revenue, By Product, 2018 – 2023 (USD Million) 69

TABLE NO. 13. : North America Oligonucleotide Synthesis Market Revenue, By Product, 2024 – 2032 (USD Million) 69

TABLE NO. 14. : North America Oligonucleotide Synthesis Market Revenue, By Application, 2018 – 2023 (USD Million) 70

TABLE NO. 15. : North America Oligonucleotide Synthesis Market Revenue, By Application, 2024 – 2032 (USD Million) 70

TABLE NO. 16. : North America Oligonucleotide Synthesis Market Revenue, By End-user, 2018 – 2023 (USD Million) 71

TABLE NO. 17. : North America Oligonucleotide Synthesis Market Revenue, By End-user, 2024 – 2032 (USD Million) 71

TABLE NO. 18. : Europe Oligonucleotide Synthesis Market Revenue, By Country, 2018 – 2023 (USD Million) 74

TABLE NO. 19. : Europe Oligonucleotide Synthesis Market Revenue, By Country, 2024 – 2032 (USD Million) 74

TABLE NO. 20. : Europe Oligonucleotide Synthesis Market Revenue, By Product, 2018 – 2023 (USD Million) 75

TABLE NO. 21. : Europe Oligonucleotide Synthesis Market Revenue, By Product, 2024 – 2032 (USD Million) 75

TABLE NO. 22. : Europe Oligonucleotide Synthesis Market Revenue, By Application, 2018 – 2023 (USD Million) 76

TABLE NO. 23. : Europe Oligonucleotide Synthesis Market Revenue, By Application, 2024 – 2032 (USD Million) 76

TABLE NO. 24. : Europe Oligonucleotide Synthesis Market Revenue, By End-user, 2018 – 2023 (USD Million) 77

TABLE NO. 25. : Europe Oligonucleotide Synthesis Market Revenue, By End-user, 2024 – 2032 (USD Million) 77

TABLE NO. 26. : Asia Pacific Oligonucleotide Synthesis Market Revenue, By Country, 2018 – 2023 (USD Million) 80

TABLE NO. 27. : Asia Pacific Oligonucleotide Synthesis Market Revenue, By Country, 2024 – 2032 (USD Million) 80

TABLE NO. 28. : Asia Pacific Oligonucleotide Synthesis Market Revenue, By Product, 2018 – 2023 (USD Million) 81

TABLE NO. 29. : Asia Pacific Oligonucleotide Synthesis Market Revenue, By Product, 2024 – 2032 (USD Million) 81

TABLE NO. 30. : Asia Pacific Oligonucleotide Synthesis Market Revenue, By Application, 2018 – 2023 (USD Million) 82

TABLE NO. 31. : Asia Pacific Oligonucleotide Synthesis Market Revenue, By Application, 2024 – 2032 (USD Million) 82

TABLE NO. 32. : Asia Pacific Oligonucleotide Synthesis Market Revenue, By End-user, 2018 – 2023 (USD Million) 83

TABLE NO. 33. : Asia Pacific Oligonucleotide Synthesis Market Revenue, By End-user, 2024 – 2032 (USD Million) 83

TABLE NO. 34. : Latin America Oligonucleotide Synthesis Market Revenue, By Country, 2018 – 2023 (USD Million) 86

TABLE NO. 35. : Latin America Oligonucleotide Synthesis Market Revenue, By Country, 2024 – 2032 (USD Million) 86

TABLE NO. 36. : Latin America Oligonucleotide Synthesis Market Revenue, By Product, 2018 – 2023 (USD Million) 87

TABLE NO. 37. : Latin America Oligonucleotide Synthesis Market Revenue, By Product, 2024 – 2032 (USD Million) 87

TABLE NO. 38. : Latin America Oligonucleotide Synthesis Market Revenue, By Application, 2018 – 2023 (USD Million) 88

TABLE NO. 39. : Latin America Oligonucleotide Synthesis Market Revenue, By Application, 2024 – 2032 (USD Million) 88

TABLE NO. 40. : Latin America Oligonucleotide Synthesis Market Revenue, By End-user, 2018 – 2023 (USD Million) 89

TABLE NO. 41. : Latin America Oligonucleotide Synthesis Market Revenue, By End-user, 2024 – 2032 (USD Million) 89

TABLE NO. 42. : Middle East Oligonucleotide Synthesis Market Revenue, By Country, 2018 – 2023 (USD Million) 92

TABLE NO. 43. : Middle East Oligonucleotide Synthesis Market Revenue, By Country, 2024 – 2032 (USD Million) 92

TABLE NO. 44. : Middle East Oligonucleotide Synthesis Market Revenue, By Product, 2018 – 2023 (USD Million) 93

TABLE NO. 45. : Middle East Oligonucleotide Synthesis Market Revenue, By Product, 2024 – 2032 (USD Million) 93

TABLE NO. 46. : Middle East Oligonucleotide Synthesis Market Revenue, By Application, 2018 – 2023 (USD Million) 94

TABLE NO. 47. : Middle East Oligonucleotide Synthesis Market Revenue, By Application, 2024 – 2032 (USD Million) 94

TABLE NO. 48. : Middle East Oligonucleotide Synthesis Market Revenue, By End-user, 2018 – 2023 (USD Million) 95

TABLE NO. 49. : Middle East Oligonucleotide Synthesis Market Revenue, By End-user, 2024 – 2032 (USD Million) 95

TABLE NO. 50. : Africa Oligonucleotide Synthesis Market Revenue, By Country, 2018 – 2023 (USD Million) 98

TABLE NO. 51. : Africa Oligonucleotide Synthesis Market Revenue, By Country, 2024 – 2032 (USD Million) 98

TABLE NO. 52. : Africa Oligonucleotide Synthesis Market Revenue, By Product, 2018 – 2023 (USD Million) 99

TABLE NO. 53. : Africa Oligonucleotide Synthesis Market Revenue, By Product, 2024 – 2032 (USD Million) 99

TABLE NO. 54. : Africa Oligonucleotide Synthesis Market Revenue, By Application, 2018 – 2023 (USD Million) 100

TABLE NO. 55. : Africa Oligonucleotide Synthesis Market Revenue, By Application, 2024 – 2032 (USD Million) 100

TABLE NO. 56. : Africa Oligonucleotide Synthesis Market Revenue, By End-user, 2018 – 2023 (USD Million) 101

TABLE NO. 57. : Africa Oligonucleotide Synthesis Market Revenue, By End-user, 2024 – 2032 (USD Million) 101

Frequently Asked Questions

What is the current size of the Global Oligonucleotide Synthesis Market?

The Global Oligonucleotide Synthesis Market is projected to grow from USD 7,452.19 million in 2023 to USD 32,652.66 million by 2032, at a compound annual growth rate of 17.84%.

What is the expected growth rate of The Oligonucleotide Synthesis Market Between 2023 and 2030?

The Oligonucleotide Synthesis Market is expected to grow at a CAGR of 16.50% between 2023 and 2030, reaching USD 21.84 billion in 2030.

What factors are driving the growth of the Global Oligonucleotide Synthesis Market?

The market’s growth is driven by increasing demand for personalized medicine, advancements in biotechnology, and rising investments in pharmaceutical research and development. Key trends include the growing application of oligonucleotides in therapeutic areas such as cancer, genetic disorders, and infectious diseases. Technological advancements and collaborations among key players are also significant contributors to market expansion.

What are the key segments within the Global Oligonucleotide Synthesis Market?

The market is segmented by product into oligonucleotide-based drugs, synthesized oligonucleotides, reagents, and equipment. It is also segmented by application into therapeutic, research, and diagnostic applications. Additionally, the market is categorized by end-user into hospitals, pharmaceutical and biotechnology companies, CROs and CMOs, diagnostic laboratories, and others.

What are some challenges faced by the Global Oligonucleotide Synthesis Market?

Challenges include delivery hurdles for oligonucleotide drugs, high manufacturing costs, regulatory complexities, quality control concerns, and ethical considerations. Overcoming these challenges is crucial for maximizing the therapeutic potential and ensuring the successful adoption of oligonucleotide-based treatments and diagnostics.

Who are the major players in the Global Oligonucleotide Synthesis Market?

Major players in the market include Thermo Fisher Scientific, Inc., Danaher Corporation, Eurofins Scientific, Kaneka Corporation, Merck KGaA, Alnylam Pharmaceuticals, Inc., Sarepta Therapeutics, Inc., Biogen Limited, Cinven, and Ionis Pharmaceuticals, Inc. These companies drive innovation and market growth through extensive research and development efforts, strategic expansions, and technological advancements.

Which segment is leading the market share?

The therapeutic applications segment is leading the market share, driven by the increasing approval and adoption of oligonucleotide-based drugs for targeted therapies in areas such as oncology, genetic disorders, and infectious diseases. This segment’s dominance is bolstered by the growing trend towards precision medicine and personalized treatment plans.

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